Cardiopulmonary Effects of Enflurane Combined with Propofol in Dogs

개에서 Enflurane과 Propofol의 병용이 심폐기능에 미치는 영향

This study was performed to evaluate cardiopulmonary depressant effects of enflurane (1.0 vol%) combined with propofol(0.25 mg/kg/min) compared with enflurane inhalation, and propofol infusion, respectively, in 18 healthy dogs premedicated with acepromazine and atropine. After bolus injection of propofol 5 mg/kg for induction and tracheal intubation, they were randomly assigned to 3 groups: propofol 0.5 mg/kg/min infusion (Group I, n=6), enflurane 2.5 vol% (Group II, n=6) and enflurane 1.0 vol% combined with propofol 0.25 mg/kg/min (Group III, n=6). Mean arterial Pressure (MAP), systolic arterial pressure (SAP) and diastolic arterial pressure (DAP) were depressed significantly in all groups, especially in Group II. MAP, SAP and DAP values of Group IIIwere higher than those of Group II, but lower than those of Group I. The changes of PaO$_2$, Pa$CO_2$and pHa were similar in all groups. Respiration rates were decreased in all groups 5 minutes after induction but maintained in normal range. Those of Group I were less depressant than those of Group II and Group III. Concentrations of $Na^+ and Cl^-$ were increased and those of $K^+$ were decreased in all groups, but their values were quitely similar. Heart rate was changed in small range and the value of Group I was higher than those of Group II and Group III. Body temperature was decreased significantly in all groups. Adverse effects like as muscle rigidity, nausea or vomiting and shivering were not appeared and apnea at induction was occured 6 dogs. From the these results, enflurane 1.0 vol% combined with propofol 0.25 mg/kg/min also could be applied for anesthesia in dogs.

일반적인 마취용량에서의 enflurane과 propofol 단독 투여와 두 마취제의 병용 투여가 심혈관계에 미치는 영향을 비교하기 위해 본 실험을 수행하였다. 진정제(acepromazine 0.05 mg/kg) 투여 후 atropine(0.05 mg/kg)으로 전처치한 실험견 18두를 3개군으로 무작위 분류하고 각 군에 propofol infusion 0.5 mg/kg/min(Group I), enflurane 2.5 vol%(Group II), enflurane 1.0 vol%와 propofol infusion 0.25 mg/kg/min(Group III)을 각각 1시간 동안 산소 공급하에서 투여하였다. 대퇴동맥에 설치한 카테터를 통하여 전 실험기간에 걸쳐 Physiograph로 MAP(Mean Arterial Pressure), SAP(Systolic Arterial Pressure), DAP(Diastolic Arterial Pressure)를 기록하고 동맥혈을 채취하여 $Na^+, K^+, Cl^-$ 등 전해질 농도와, PaO$_2$(arterial oxygen tension), Pa$CO_2$(arterial carbon dioxide tension), pHa(arterial pH)를 측정하였다. 마취 전후의 체온, 심박수, 호흡수를 측정하였다. 특히 심혈관계와 관계된 검사(MAP, SAP, DAP, 체온)에서 마취유도 후 20분 동안은 모든 group에서 감소가 뚜렷하였다. Group II와 Group III에서 유의적인 감소(p<0.05, 0.01)를 보였으며 Group III는 Group I보다는 낮았으나 Group II보다는 높은 수치를 기록하였다. 산소공급과 관련하여 PaO$_2$의 증가(p<0.05, 0.01)가 있었으며 전해질 검사에서는 $Na^+와 K^+$의 유의적인 변화(p<0.05, 0.01)가 나타났다. 실험결과 유의성있는 변화가 나타났지만 모든 결과들이 정삼범위내에 있었고 뚜렷한 부작용이 나타나지 않았으므로 enflurane 1.0 vol%와 proofol 0.5 mg/kg/min 병용투여는 개 마취에 있엇 적용가능한 방법이라 생각된다.