동충하초 자실체가 흰쥐가 성장률, 지질과 단백질 대사 및 효소활성에 미치는 영향

Effect of Fruiting Body of Cordyceps Militaris on Growth, Lipid and Protein Metabolism, and Enzyme Activities in Male Rats

  • 고진복 (신라대학교 생명과학과)
  • 발행 : 2001.10.01

초록

The effects of fruiting body of Cordyceps militaris on the growth, the food intake, the food efficiency ratio, the lipid metabolism, the serum protein level ad enzyme activity in male rats were studied. Sprague-Dawley rats were fed four types of diets for five weeks, respectiely: a control diet, a control diet supplemented with 2%, 3% or 4% fruiting body of Cordyceps militaris(CF) powder. In rats fed 2% or 3% CF diets the body weight gain, the food intake, the concentratons of hepatic triglyceride and serum LDL-cholesterol, the atherogenic index, and the total lipid, total cholesterol, triglyceride and phospholipid in serum were similar to those in rats fed the control diet. Whereas, in 4% CF diet these were significantly decrased. But the all CF diets feeding could not decrease the food efficiency ratio, the weights of liver, pancreas, spleen, kidney and heart, and the concentration of serum HDL-cholesterol. Also, it was shown that the concentrations of glucose, total protein, albumin, urea and creatinine, and the GOT, GPT, LDH, ${\gamma}$-GTP and ALP activities were the same levels in serum of rats of fed all the experimental diets.

키워드

참고문헌

  1. Trans Brit Mycol Soc v.20 Cordyceps militars and isaria farinisa Petch T
  2. Trans Brit Mycol Soc v.32 Cordyceps aphodii, a new species, on pasture cockchater grubs Mathiexon J
  3. Biological control Insect past suppression Coppel HC;Mertins JW
  4. Mycologia v.50 North American entomogenous Cordyceps Mains EB
  5. Cordyceps of Korea Sung JM
  6. STokyo Bunrika daikaku Sect v.B5 The genus Cordyceps and its allies. Sci. Rept. Kobayasi Y
  7. Icons of Medicinal Fungi from China Science Press China Jianzhe Y;Xiaoloan M;Qiming M;Yichen Z;Huaan W
  8. USDA Agricultural Research Service Fungal pathogens of insects, spiders, and mites : isolation, preservation and identification Humber RA
  9. Color iconography of vegetable wasps and plant worms Shimizu D
  10. Cordyceps sinensis Part II. J Altern Complement Med v.4 no.3 The scientific rediscovery of an ancient Chinese herbal medicine Zhu JS;Halpern GM;Jones K
  11. Cancer Invest v.12 no.6 Growth inhibitors against tumor cells in codyceps sinensis other than cordycepin and polysaccharides Kuo YC;Lin CY;Tasi WJ;Wu CL;Chen CF;Shiao MS
  12. Nature v.166 Cordycepin, a metabolic product from cultures of Cordyceps militaris(Linn) Link Cunningham YC;Manson W;Spring FS;Hutchinson SA
  13. Arch Biochem Biophys v.144 Effect of 3'-deoxyadenosine(cordycepin) and 2'-deoxydenosine on nucleoside transport, macromolecular synthesis, and replication of cultured Novikoff hepatoma cells Plagemann FG;Erbe J
  14. Biochem Biophys Acta v.80 The inhibition of purine biosynthesis de noveo in Bacillus by cordycepin Rottman F;Guatino A
  15. J Biol Chem v.255 Inhibition of nucleic acid methylation by cordycepin Kredich NM
  16. J Cell Physiol v.140 Enhanced messenger RNA stability and cordycepin Mathew PA;Ellis LK;Studzinski GP
  17. Biochem Pharmacol v.26 Inhibition effects of cordycepin on cyclic nucleotide-dependent and cyclic nucleotide-independent protein kinases Glazer RI;Kuo JF
  18. Cancer Res v.21 Inhibition of Ehrlich mouse ascites tumour growth by cordycepin Jagger DV;Kredich NM;Guarino AJ
  19. Bichem Biophys Acta v.80 Effect of cordycepin triphosphate on the incorporation of (8-14C) adenine and (37P) orthophosphatic into the acid-soluble ribotides of Ehrlich mouse ascites tumour cells Klenow H;Overgaard-Hansen K
  20. Biochim Biophys Acta v.80 The inhibition of 5-phosphoribosyl-1-pyrophosphate formation by cordycepin triphosphate in extracts of Ehrlich mouse ascites tumour cells Overgaard-Hansen K
  21. Int J Cancer v.36 Differential antiproliferative actions of 2', 5' oligo a trimer core and its cordycepin analogue on human tumor cells Hubbel HR;Pequignot EC;Willis DH;Lee C;Suhadolnik RJ
  22. Can J Bot v.46 Studies on the production of perithecial stromata by Cordyceps militaris in artificial culture Basith M;Madelin MF
  23. Korean J Mycology v.27 Production of fruiting body Using Cultures of entomopathogenic fungal species Sung HM;Choi YS;Lee HK;Kim SH;Kim YO;Sung GH
  24. Inje University J v.12 Consideration of phamacological functions of components in Cordyceps militaris Park HJ;Choi MA
  25. J Food Sci Nutr v.4 Identification and antibacterial activity of volatile flavor components of Cordyceps militaris Choi MA;Lee WK;Kim MS
  26. Korean J Nutrition v.34 no.3 Effect of Cordyceps militaris on lipid metabolism in rats fed cholesterol diet Koh JB;Choi MA
  27. J Nutr v.123 AIN-93 purified diets for laboratory rodents final report of the American Institute of Nutrition adhoc writing committee on the reformulation of the AIN-76A rodent diet Reeves PG;Nielsen FH;Fahey GC
  28. Technology and Clinical Pathology(2th ed.) Medical Laboratory
  29. Todd-Sanford Clinical Diagnosis by Laboratory Methods(13th ed.) Davidson I;Henry JB
  30. Clin Chem v.18 Estimation of concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge Friedewald WT;Levy RI;Fedreison DS
  31. Eur J Nutr v.121 The effect of fish oil on triglycerides, cholesterol, fibrinogen and malondialdehyde in humans supplemented with vitamin Haglund O;Loustarinen R;Wallin I;Saldeen T
  32. J Biol Chem v.226 A simple method for the isolation and purification of total lipid from animal tissues Folch J;Lees M;Stanley GSH
  33. Am J Clin Path v.53 A colormetric method for determination of total serum lipid based on the sulfopholpho-vanillin reaction Frings CS;Dunn RT
  34. Korean J Nutrtition v.34 no.3 Effect of dried powders and water extracts of Paecilomyces tenuipes and Codyceps militaris on lipid metabolism, antidxidative capacity and immune status in rats Kwon SH;Woo HJ;Han DS;Kim MK
  35. Biol Pharm Bull v.19 no.2 Polysaccharides in fungiXXXVI. Hypoglycemic activity of polysaccharide(CS-F30) from the cultural mycelium of Cordyceps sinensis and its effect on glucose metabolism in mouse liver Kiho T;Yamane A;Hui J;Usui S;Ukai S
  36. Pharmacological effect on Cordyceps sinensis paper presented at 1st international symposium on Coedyceps Lin Y
  37. Korean J Lab Ani Sci v.9 Effects of the population density on growth and various physiological values of Sprague-Dawley rats Kim HY;Song SW;Ha CS;Han SS
  38. Korean J Lab Ani Sci v.11 Reference values of hematology and serum chemistry in Ktc : Sprague-Dawley rats Kang HB;Son HY;Ha CS;Song SW