Journal of environmental and Sanitary engineering (환경위생공학)

Korean Society for Environmental Sanitary Engineers (대한환경위생공학회)
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Effects of sodium molybdate on phospholipid metabolism in peripheral nerves of lead-intoxicated rats.

Sodium molybdate가 납중독 랫드의 말초신경내 인지질 대사에 미치는 영향

  • 박성환 (선문대학교 환경공학과) ;
  • 정명규 (선문대학교 환경공학과) ;
  • 곽영규 (동의공업대학 환경시스템공학과)
  • Published : 2001.09.01
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Abstract

The effects of sodium molybdate(Mo) on phospholipid metabolism in sciatic nerve isolated from lead-intoxicated rat were investigated. Four weeks aged albino rats were divided into four groups : normal control group, lead(10 ppm)-treated group, Mo(1 mg/kg)-treated group, lead and Mo-treated group. As a result of the study, Mo significantly increased the rate of incorporation of $2-[^3H]$myo-inositol into polyphosphinositides in lead-intoxicated rat. Mo also increased the rate of phosphatidylcholine metabolism in normal and lead-intoxicated rats. However, Mo did not affect the metabolism of phosphatidylserine and phosphatidylethanola-mine in normal and lead-intoxicated status. These results suggest that Mo might improve lead-intoxicated status by principally enhancing the metabolism of myo-inositol-related phospholipids and by partly phosphatidylcholine in sciatic nerve.

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References

  1. Proc. Natl. Acad. Sci. v.77 Inborn errors of molybdenum metabolism : combined defieciencies of sulfide oxides and xanthion oxidase in a patient lacking the molybdenum cofactor Johnson, J.I.;W.D. Wane
  2. 한국환경과학회지 v.9 no.3 Sodium molybdate의 납중독성 말초 신경계독성 예방기전 정명규;강순국;김명녀
  3. J. Neurochem. v.17 Sodium and energy dependent uptake of myoinositol by rabbit peripheral nerve. Greene D.A.;Lattimer S.A.
  4. J. Biol. Chem. v.247 Determination of myo-inositol content in red blood cell. Buckkley J.T.;Hawthrone, J.N.
  5. Cyclitols and Phosphoinositides. Posternak T.H.
  6. Science v.217 Significance of tissue myo-inositol concentrations in metabolic regulation in nerve. Simmons, D.A.;Wingard A.I.;Martin D.B.
  7. J. Clin. Invest. v.77 Basal phophatidylinositol turnover controls aortic sodium-potassium ATPase activity Simmons D.A.;Kern E.F.;Wingrad A.I.;Martin D.B.
  8. Biochem. J. v.220 Inositol triphosphate and diacylglycerol as second messenges Berridge M.J.
  9. 대한환경공학회지 v.16 no.5 중금속의 독성기전에 관한 연구 정명규;임경택;정현옥
  10. J. Neuro. Sci. v.23 peripheral nerve structure and function in experimental diabetes Shrama, A.K.;Thomas, P.K.
  11. J. Neurocem. v.39 no.1 Metabolism of phospholopids in peripheral nerve from rats chronic streptozotocin induced diabetes : Increased turnover of phosphatidylinositol-4, 5-biphosphate. Bell, M.E.;Peterson, R.G.
  12. Number, Cruuncher : Statistical system Jerry, L.H.
  13. Biochem. J. v.100 The polyphosphoinositides and other lipids of peripheral nerves Sheltawy A.;Dawson R.M.