생명과학회지 (Journal of Life Science)

  • 제11권6호
  • /
  • Pages.543-553
  • /
  • 2001
  • /
  • 1225-9918(pISSN)
  • /
  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
권호 표지

납중독에 대한 마늘의 치료와 방어효과

Curative and Protective Effects of Garlic on Lead Poisoning

  • 이용환 (고신대학교 의학부 예방의학교실) ;
  • 박명호 (고신대학교 의학부 예방의학교실) ;
  • 최명원 (고신대학교 의학부 예방의학교실) ;
  • 천봉권 (고신대학교 의학부 병리학교실) ;
  • 허방 (고신대학교 의학부 병리학교실) ;
  • 탁효정 (고신대학교 보건과학부 환경보건학과) ;
  • 황인철 (고신대학교 보건과학부 환경보건학과)
  • Lee, Yong-Hwan (Department of Preventive Medicine, College of Medicine, Kosin University) ;
  • Park, Myung-Ho (Department of Preventive Medicine, College of Medicine, Kosin University) ;
  • Choi, Myung-Won (Department of Preventive Medicine, College of Medicine, Kosin University) ;
  • Chun, Bong-Kwon (Department of Pathology, College of Medicine, Kosin University) ;
  • Hur, Bang (Department of Pathology, College of Medicine, Kosin University) ;
  • Tak, Hyo-Jung (Department of Environment and Health, Kosin University) ;
  • Hwang, In-Chul (Department of Environment and Health, Kosin University)
  • 발행 : 2001.12.01
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초록

마늘 속에서 중금속 중독 시에 킬에이트 작용을 일으킬수 있다는 다량의 황 화합물이 함유되어 있으므로 납 중독 흰쥐에서 그 효과를 확인하고자 본 연구를 실시한 결과 마늘 500mg/kg 투여 흰쥐군에서 유의한 납 배설량의 증가가 있었으며, 납과 마늘의 동시에 투여했을 경우에는 납 단독 투여군 보다 신장에서의 병리조직학적 변화가 경미한 것을 관찰할수 있었다. 이러한 결과는 마늘이 납 중독에대한 킬레이트제로서의 이용 가능성이 있음을 나타내고 있다.

Lead poisoning is currently one of the major public health problems in industrialized countries. Several chelating agents have been developed and used to treat the lead poisoning. It was recently proposed that garlic, having a large quantity of S-S compounds, may react readily with lead, producing various sulfur componds, and thus provide curative and protective effects on the lead toxicity. The present study was undertaken to evaluate this possibility in experimental animals. The garlic treatment on rats pre-exposed to lead significantly enhanced urinary excretion of lead at a garlic dose of 500 mg/kg and decreased the bloon level of lead at both 250 and 500 mg/kg doses. The administration of grilic 500mg/kg along with lead significantly alleviated the renal histological alterations induced by lead. These results suggest that garilic has a curative as well as a protective effect against lead poisoning , thus it may act as a chelator of lead.

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