KSBB Journal

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Controlled Rrelease of Indomethacin using Biodegradable Polymer Microspheres

생분해성 고분자 미세구를 이용한 indomethacin의 방출제어

  • Lim, Seung (Faculty of Chemical Engineering & The Research institute for Catalysis) ;
  • Lee, Ki-Young (Faculty of Chemical Engineering & The Research institute for Catalysis) ;
  • Lee, Moo-Sung (Faculty of Applied Chemistry, Chonnam National University) ;
  • Choi, Chang-Nam (Faculty of Applied Chemistry, Chonnam National University) ;
  • Kim, Young-Dae (Faculty of Applied Chemistry, Chonnam National University)
  • 임승 (전남대학교 화학공학부 및 촉매 연구소) ;
  • 이기영 (전남대학교 화학공학부 및 촉매 연구소) ;
  • 이무성 (전남대학교 응용화학부) ;
  • 최창남 (전남대학교 응용화학부) ;
  • 김영대 (전남대학교 응용화학부)
  • Published : 2001.10.01
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Abstract

The preparation, characterization and drug release behaviour of drug(indomethacin) loaded Poly(L-lactic acid)(PLA), tarmarind acetate and levan acetate mircospheres were investigated. Hydrophobic tarmarind acetate and levan acetate were prepared by chemical modification of hydrophilic tarmaried gum and levan and microspheres were made by a solvent evaporation method. In the case of poly(L-lactic acid) microspheres, drug release rate was effected by polymer-drug ratios and drum release was sustained by increasing of polymer content. The yield of microspheres were effected by many factors and the mean size was below 1 $\mu$m, The IND release profiles from tarmarind acetate and levan acetate micropheres were more slightly less than ploy(L-lactic acid) microspheres.

생분해성 합성고분자인 PLA와 천연고분자 물질 tamarind gum과 levan을 불용화시킨 다당 아세타이트를 solvent evaporation 방법을 통해 약물(indomethacin)이 포함된 미세구를 제조하였다. PLA 미세구의 경우, 약물의 방출속도는 함유된 약물의 양에 따라 달라졌으며 담체의 비율이 증가할수록 약물의 방출이 지연되었다. 다당 아세테이트를 이용해서 제조한 미세구의 경우에도 방출지연 효과가 있었다. 이러한 점들을 고려해볼 때 본 실험에서 사용한 생체분해성 고분자 미세구들이 방출지연담체로 사용될수 있음을 알 수 있었다.

Keywords