Fibers and Polymers

The Korean Fiber Society (한국섬유공학회)
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Relationships between Antithrombogenicity and Surface Free Energy of Regenerated Silk Fibroin Films

  • Park, Won Ho (Department of Textile Engineering, Chungnam National University) ;
  • Ha, Wan Shik (Department of Fiber and Polymer Science, Seoul National University) ;
  • Ito, Hiraku (Saint Agnes Junior College, Nanpeidai, Takatuki) ;
  • Miyamoto, Takeaki (Institute for Chemical Research, Kyoto University) ;
  • Inagaki, Hiroshi (Institute for Chemical Research, Kyoto University) ;
  • Noishiki, Yasuharu (First Department of Surgery, School of Medicine, Yokohama City University)
  • Published : 2001.06.01
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Abstract

Silk fibroin (SF) was dissolved in calcium chloride/ethanol/water mixture(1/2/8 in mole ratio) at $70^{\circ}C$ for 4h. The dissolved silk fibroin was regenerated by casting the dialyzed solution into films. The films were treated with 50% aqueous solution of methanol for different times, and their antithrombogenicity was evaluated by in vivo tests. In vivo blood tests were made by a method of peripheral vein indwelling suture. It was found that the silk fibroin had a good antithrombogenicity and an absorbability even though the polymer showed foreign body reaction. Finally, the blood compatibilty of silk fibroin films which were subjected to structural change by the methoanl treatment, was examined in connection with their interfacial surface energy, and a correlation between these properties was found to be present.

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