Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Anti-Angiogenic Activity of Acalycixenolide E, a Novel Marine Natural Product from Acallycigorgia inermis

  • Kwon, Ho-Jeong (Department of Bioscience and biotechnology, Sejong University) ;
  • Kim, Jin-Hee (Department of Bioscience and biotechnology, Sejong University) ;
  • Jung, Hye-Jin (Department of Bioscience and biotechnology, Sejong University) ;
  • Kwon, Yong-Guen (Division of Life Science, College of Natural Science, Kangwon National University) ;
  • Kim, Min-Young (AngioLab, Inc., Pai Chai University) ;
  • Rho, Jung-Rae (Marine Natural product Laboratory, Korea Ocean Research and Development Institute) ;
  • Shin, Jong-Heon (Marine Natural product Laboratory, Korea Ocean Research and Development Institute)
  • Published : 2001.08.01
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Abstract

Angiogenesis is known as a crucial process in the growth and spreading of tumor cells. Accordingly, the effective inhibition of this process would appear to be a promising way to cure angiogenesis-related diseases, including cancer. This study demonstrates that acalycixenolide E (AX-E) from the marine organism Acalycigorgia inermis exhibits a potent anti-angiogenic activity both in vitro and in vivo. AX-E inhibits the bFGF-induced proliferation of HUVECs in a dose dependent manner, along with the bFGF-induced migration, invasion, and tube formation of HUVECs. Moreover, AX-E potently inhibits the in vivo neovascularization of the chorioallantoic membranes (CAMs) of growing chick embryos. interestingly, AX-E suppresses the expression of metalloproteases 2 and 9, yet shows no effect on their activities. The novel chemical structure and potent anti-angiogenic activity of AX-E will be of great value in elucidating the molecular mechanism of angiogenesis as well as in the development of a novel anti-angiogenic drug.

Keywords

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