Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Anti-Allergic and Anti-Asthmatic Activity of Helioscopinin-A, a Polyphenol Compound, Isolated from Euphorbia helioscopia

  • Park, Kwan-Ha (Department of Marine Biomedical Sciences, Kunsan National University) ;
  • Koh, Dong-Soo (Department of Applied Chemistry, Dongduk Women’s University) ;
  • Lee, Seung-Ho (College of Pharmacy, Yeungnam University) ;
  • Jung, Ill-Min (Department of Crop Science, Konkuk University) ;
  • Kim, Kyung-Hyun (Graduate School of Biotechnology, Korea University) ;
  • Lee, Chul-Hoon (Department of Medical Genetics and Institute of Biomedical Science, College of Medicine, Hanyang University) ;
  • Kim, Kye-Hoon (Department of Environmental Horticulture, The University of Seoul) ;
  • Lim, Yoong-Ho (Department of Applied Biology and Chemistry, Konkuk University)
  • Published : 2001.02.01
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Abstract

During the course of searching for anti-allergic substances from unexplored plant sources, an inhibitor of leukotriene $D_4$-induced tracheal contraction was isolated from Euphoribia helioscopia. This isolated polyphenol compound, known as helioscopinin-A, showed a certain inhibitory activity on capillary permeability in passive cutaneous anaphylaxis responses of rats and also on antigen-induced bronchial constriction in an experimental asthma model of guinea pigs. The compound at a high concentration weakly inhibited histamine release from isolated mast cells of rats. It is suggested that this compound is an anti-allergic and anti-asthmatic which exerts its activity through antagonism on leukotrene $D_4$-induced responses. A partial inhibition of allergic mediator relase may also bee involved.

Keywords

References

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