Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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In Vitro Activities of 2,2'-Dipyridyl Against Trichomonas vaginalis, Candida albicans, and Gardnerella vaginalis

  • Ryu, Jae-Sook (Department of Parasitology, Hanyang University College of Medicine) ;
  • Min, Duk-Young (Department of Parasitology, Hanyang University College of Medicine) ;
  • Kim, Myeong-Cheol (Department of Parasitology, Hanyang University College of Medicine) ;
  • Kim, Nam-Sik (Department of Parasitology, Hanyang University College of Medicine) ;
  • Shin, Myeong-Heon (Department of Parasitology, College of Medicine, Ewha Womans University)
  • Published : 2001.02.01
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Abstract

The in vitro activities of 2,2'-dipyridyl, an iron-chelator, against clinical isolates of Trichomonas vaginalis, Candida albicans, and Gardnerella vaginalis was evaluated and compared with those of four other vaginal suppositories, ornidazole, clotrimazole, povidone-iodine, and $Cenacert^{\circledR}$ (Methylbezethonium Chloride mixed with 9-aminoacrydine undecylenate and hydrochloric acid N-myristyl-3-hydroxy butyl amine). The 2,2'-dipyridyl killed T. vaginalis and G. vaginalis at concentrations of $410\;{\mu}g/ml$ and $205\;{\mu}g/ml$, respectively, however, ths agent was less active against C. albicans (80% of which was inhiited at $410\;{\mu}g/ml$). The inhibition of these three pathogens by 2,2'-dipyridyl was similar to clotrimazole. In addition, the effect of 2,2'-dipyridyl on the ultrastructure of T. vaginalis, C. albicans, an G. vaginalis was examined. Transmission electron microscopy indicated that 2,2'-dipyridyl induced modifications of the cellular contents and cell envolope concumitant with the degradation of the three pathogens. These results suggest that 2,2'-dipyridyl has an inhibitory effect on C. albicans and G. vaginalis, as well as T. vaginalis.

Keywords

References

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