Statistical Analysis of Bioequivalence Study in 2x3 Cross-over Design

  • Lim, Nam-Kyoo (Department of Applied Statistics, Chung-Ang University)
  • 발행 : 2001.08.01

초록

The 2x3 cross-over design is proposed for the bioequivalence of two test drug formulations with a reference drug formulation. Oh et al.(1999) and Park et al.(1998) derived 3x2 cross-over design and discussed its benefits, since the 3x3 cross-over design may not be of practical design. We discuss the statistical issues for2x3 cross-over design and show its statistical properties. Bioequivalence problem in 2x3 cross-over design is considered statistically and an illustrated example is given.

키워드

참고문헌

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