Journal of Photoscience

Korean Society of Photoscience (한국광과학회)
권호 표지

The Synthesis of Chlorin-based Photosensitizers for using in Photodynamics Therapy by Modification of Methyl Pyropheophorbide-a

  • Wang, Jin-Jun (Bio-Organic Science Division, Korea Research Institute of Chemical Technology) ;
  • Han, Guang-Fan (Bio-Organic Science Division, Korea Research Institute of Chemical Technology) ;
  • Shim, Young-Key (Bio-Organic Science Division, Korea Research Institute of Chemical Technology)
  • Published : 2001.06.01
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Abstract

The Grignard reaction of methyl pyropheophorbide-a (MPP-a) was performed to introduce lengthy alkyl chain for improving lipophilicity. After the introduction of alkyl chain to the both of carbonyls, peripheral aldehyde and cyclopentanone, the obtained diol 3 was subjected to dehydration to give monodehydrate product 4 selectively. The Qy band of prepared compounds were affected by the substituents on the Qy axis (N$\sub$21/-N$\sub$23/).

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References

  1. J. Porphrins Phthalocyanines v.5 Basic principle of photodynamic therapy Macdonald I.A.;Thomas J.D.
  2. Tetrahedron v.54 Porphrin-based photosensitizers for use in photodynamic therapy Sternberg E.D.;David D.
  3. Photochem. Photobiol. v.64 Chlorophyll and bacteriochlorophyll derivates, potentially new photodynamic agents Rosenbach B.V.;Fiedor L.;Pavlotsky F.;Salomon Y.;Scherz A.
  4. Cancer research v.57 An in vivo quantitative structure-activity relationship for a congeneric series of pyropheophorbide derivatives as photosensitizers for photodynamic therapy Barara W.H.;David A.B.;William;R.G. Amaynath S.;Ravindra K.P.;Lurine A.V.;Kenneth R.W.;Thomas J.D.
  5. J. Am. Chem. Soc. v.107 Mesosubstitution of chlorophyll derivatices: Direct rout for transformation of bacteriopheophorbide d into bacteriopheophorbide Smith K.M.;Goff D.A.;Simpson D.J.