Journal of Ginseng Research
- 제25권2호
- /
- Pages.74-81
- /
- 2001
- /
- 1226-8453(pISSN)
- /
- 2093-4947(eISSN)
Xenopus oocytes에서 발현된 유전자재조합 세로토닌 제3형 수용체에 대한 한국산 홍삼 사포닌의 효과
The Effect of Korean Red Ginseng Saponins on the Recombinant Serotonin Type 3 Receptor Expressed in Xenopus Oocytes
초록
The effect of Korean Ginseng saponins (total saponin, PD saponin and PT saponin) on the serotonin type 3 receptor, which is known to be involved in nausea and vomiting following anticancer chemotherapy or the general anesthesia, was investigated. after in vitro transcribed recombinant serotonin type 3 receptor in the Xenopus laevis oocyte, classic two electrodes voltage clamp technique was used. All of ginseng saponins inhibited the response of the agonist, serotonin, on the serotonin type 3 receptor in a dose-dependent manner. PT saponin showed to have the inhibitory effect more than 2 times as potent as PD saponin. Total saponin shifted the serotonin dose response plot to the right (EC
키워드