KIEE International Transactions on Electrophysics and Applications
- Volume 11C Issue 2
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- Pages.23-27
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- 2001
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- 1598-2610(pISSN)
Highly Integrated DNA Chip Microarrays by Hydrophobic Interaction
- Park, Yong-Sung (Institute of Scientific and Industrial Research, Osaka University) ;
- Kim, Do-Kyin (Division of Electrical, Electronics and Computer Eng., Dong-A University) ;
- Kwon, Young-Soo (Division of Electrical, Electronics and Computer Eng., Dong-A University)
- Published : 2001.06.01
Abstract
Microarray-based DNA chips provide an architecture for multi-analyte sensing. In this paper, we report a new approach for DNA chip microarray fabrication. Multifunctional DNA chip microarrays were made by immobilizing many kinds if DNAs on transducers (particles). DNA chip microarrays were prepared by randomly distributing a mixture of the particles on a chip pattern containing thousands of micro meter-scale sites. The particles occupied different sites from array to array. Each particle cam be distinguished by a tag that is established on the particle. The particles were arranged on the chip pattern by the random fluidic self-assembly (RFSA) method, using hydrophobic interaction.
Keywords
- DNA chip microarray;
- Random fluidic self-assembly;
- Hydrophobic interaction;
- Particle;
- Chip pattern;
- Photolithography;
- Primary DNA;
- Complementary DNA