The Study of Relation Among Serum Copper, Zic, Leptin and Lipids of Middl-school Girls

일부 사춘기 여중생의 혈청 구리, 아연함량과 혈청 렙틴 및 지질과의 관계

  • 김미현 (숙명여자대학교 식품영양학과) ;
  • 이윤신 (수원여자대학 식품과학부) ;
  • 이다홍 (숙명여자대학교 식품영양학과) ;
  • 박혜순 (울산의대 서울중앙병원 가정의학과) ;
  • 승정자 (숙명여자대학교 식품영양학과)
  • Published : 2001.06.01

Abstract

The purpose of this study was to investigate the relationship among nutritional status of copper and zinc, serum leptin, and lipids of 99 middle school girls residing in kyunggi-do, Korea. Subjects were divided assigned to one of two groups such as normal (BMI<85 percentile, n=58) and obese (85$\leq$BMI, n=41) groups. Subjects were evaluated based on anthropometric measurements, 24-hr dietary recalls and blood analysis. The mean age was 13.93 years. The mean weight (p<0.001), BMI (p<0.001), body fat (p<0.001) of obese were significantly higher then those of normal group. The mean daily energy intake was 94.2% of RDA for Korean. The ratio of energy coming from carbohydrate, fat and protein was 63:24:13. The mean daily intakes of Cu and Zn were 1.4 mg and 7.4 mg (73.7% of RDA), and there were no significant difference between two groups. The mean serum levels of leptin (p<0.001), LDL-cholesterol (p<0.05), triglyceride (p<0.01), TPH (total cholesterol/HDL; p<0.001), LPH (LDL/HDL; p<0.001) and AI (atherogenic index; p<0.001) of obese were significantly higher than those of normal group. The mean serum Cu level of obese was significantly higher than normal group but, the mean serum Zn level of obese was significantly lower than normal group. Serum Cu showed a significantly positive correlations with body weight (p<0.001), BMI (p<0.001), body fat (p<0.001), serum leptin, and LPH. However, serum Zn showed a significantly negative correlations with body weight (p<0.001), BMI (p<0.001), serum leptin (p<0.001), TPH (p<0.05), and AI (Atherogenic index; p<0.05). To summarize the results, the Zn intakes of middle school girls did not reach to RDA for Koreans. Also, increase of BMI may lead to decrease of serum zinc level and increase of serum copper level, and this change of serum zinc related to the change of serum leptin and serum lipids level in middle school girls during rapid growth.

Keywords

References

  1. J. Kor Aca. Family Med. v.18 Body image perception and self-reported weight control activities in adolescent girls Hong, E.K.;Park, S.B.;Shin, Y S.;Park, H S
  2. J. Kor. Med. Asso. v.39 Eating disorder on adolesence Ahn, D.H.
  3. Kor. J Comm Nutr. v.3 An ecological study on eating behavior of middle school students in Seoul Kim, J H;Choi, J H.;Lee, M.J.;Moon, S.J
  4. Acta Paediatr. Scand. v.80 Mineral metabbolism in obese children after weight loss Zamboni, G;Antoniazzi, F.;Spolettni, E.;Tato, L.
  5. Int J. Obes. Relat. Metab. Disord. v.16 Bone structure and calcium metabolism in obese Zucker rats Foldes, J;Shih, M.S;Levy, J.
  6. Proc Natl. Sci Coinc. Repub. China[B] v.11 Effect of zinc and thvroxine treatment on dietary-obese mice Lind, W.H.;Chen, M D.;Cheng, V.;Tsou, C.T;Wang, Y S.;Lin, E.
  7. Przegllea v.51 Serum zinc and copper in blood serum in children and young people between 5 and 18 years of age Laitmen, R;Vuori, E;Vukari, J.
  8. Acta Paediatr. Jpn. v.39 Serum, zinc, copper, and magnesium levels in obese children Yakinci, C.;Pac, A;Kucukbay, F.;Tayfun, M;Gol, A.
  9. Cell. v.84 Evi-Identification of a mutation in the leptin receptor gene in db/db mice Chen, H.;Charlat, O.;Tartaglia, L.A.;Woolf, E A.;Weng, X.;Ellis, S J;Lakey, N D.;Culpepper, J.;Moore, K J;Breitbart, R E;Duyk, G.M.;Tepper, R.;Morgenstern, J.P.
  10. J. Med. v.24 Relationship between zinc and obesity Di Martino, G.;Matera, M.G.;De Martino, B;Vacca, C.;Di Martino, S;Rossi R.
  11. Am. J. Clin. Nutr. v.65 Copper status of young men consuming a low-copper diet Turnlund, J.R.;Scott, K.C.;Peiffer, G.L.;Jang, A.M.;Keyes, W.R;Keen, C.L.;Sakanashi, T.M.
  12. Nutr. Rev. v.53 Zinc and human health Aggett, P.J.;Comerford, J.G
  13. Am. J. Clin Nutr. v.53 Discovery of human zinc deficiency and studies in an experimental human model Prasad, A S
  14. Nature v.372 Positional cloning of the mouse obese gene and its human homologue Zhang, Y.;Proenca, R;Maffel, M.;Barone, M.;Leopold, L;Friedman, J.M
  15. Proc. Natl Acad. Sci. v.94 Physiological response to long-term peripheral and central leptin infusion in lean and obese mice Halaas, J.L.;Boozer, C.;Blair-West, J;Fidahusein, N.;Dentons, D.A.;Friedman, J M.
  16. Science v.269 Effects of the obese gene product on body weight regulation in ob/ob mice Pellymounter, M.A;Cullen, M.J.;Baker, M.B.;Hecht, R.;Winters, D.;Boone, T.
  17. Kor J. Nutr. v.33 The study of relationship among serum leptin, nutritional status, serum glucose and lipids of middle-school girls Kim, M.H;Sung, C J
  18. N. Engl. J. Med v.334 Serum immuno-reactive-leptin concentrations in normal-weight and obese humans Considine, R.V;Sinha, M K.;Heiman, M L;Kriauciunas, A.;Stephens, T.W.;Nyce, M.R.;Ohannesian, J.P;Marco, C.C;McKee, L.J.;Bauer, T.L.;Caro, J F.
  19. Clin. Endocrinol v.46 Serum leptin concentrations in patients with anorexia nervosa, bulimia nervosa and non-specific eating disorders correlate with the body mass index but are indepedent of the respective disease Ferron, F.;Considine, R V.;Peino, R.;Lado, I.G.;Dieguez, C.;Casanueva, F F
  20. Nat Med. v.2 Gender differences in plasma leptin concentrations Havel, P J;Kasim-Karakas, S.;Dubuc, G.R;Mueller, W;Phinney, S.D.
  21. FASEB v.11 Blood leptin levels are reduced during zinc deficiency induced anorexia Mangtan, H F.;Paul, G.L;Shay, N.F
  22. J. Am. Coll. Nutr. v.17 Zinc may regulate serum leptin concentration in humans Mantzoros, C.S;Prasad, A.S.;Beck, F.W J.;Grabowski, S.;Kaplan, J;Adair, C.;Brewer, G J.
  23. Standard growth chars of Korean children and adolescent in 1998 Korean Pediatric Society
  24. Food composition table fifth revision National Rural Living Science Institute
  25. Food composition and nutrition tables Souci, S.W.;Fachmann, W;Kraut, H.
  26. 食品の微量元素含量表 鈴木泰夫;田主澄三
  27. Circulation. v.61 Estimation of the concentration of low density lipoprotein cholesterol distribution : The lipid research clinics programs prevlence study Fredwald W.T.;Levy, R.I;Fredrickson, D S.
  28. The Mucatine Study Pediatrecs v.82 Factors affectin the relationship between childhood and adult cholesterol levels Lauer, R.M.;Lee, J.;Clarke, W P.
  29. Recommended dietary allowances for Koreans(7th revision) The Korean Nutrition Society
  30. J Kor. Pediatr. Soc v.37 A study on serum levels of cholesterol and HDL-cholesterol in normal elementary children Sim, J K;Jeon, M.J;Hwang, M.S.
  31. Kor. J. Nutr. v.26 Eating behavior, obesity and serum lipid levels in children Yim, K.S.;Yoon, E.Y.;Kim, C I.;Kim, K T.;Kim, C.I.;Mo, S.M;Choi. H M
  32. Recommended dietary allowances(10th edition) National Reserch Council
  33. M.S. Thesis. A study on nutritional status of iron, copper and zinc in Korean normal and obese elementary school students Lee, S.Y.
  34. Ph.D. Dissertation Nutritional status, immune response and trace minerals in Korean urban young women according to body mass index Lee, H.O.
  35. Kor. J. Nutr v.24 The study on concentration of serum copper and zinc in stormach cancer patients Chung, Y.D;Hong, S.I.;Na, H.B.;Shim, Y H.
  36. J. Med Assoc. Tnai. v.79 Serum zinc and copper in heatlthy adults living in Bangkok and surrounding districts Songchitsomboon, S;Komindr, S.
  37. Physiol. Res v.43 Serum copper, zinc and copper/zinc ratio in males: influence of aging Madaric, A.;Ginter, E;Kadrabova, J.
  38. Adv. Exp Med. Biol. v.258 Effect of estrogen on serum and tissue levels of copper and zinc Mehta, S.W.;Eikum, R.
  39. Fertill. Steril. v.33 Serum copper and zinc in hormonal constraceptive users Prema, K.;Ramalakshmi, B A.;Babu, S.
  40. Kor. J. Nutr v.29 The relationship between dietary intakes, serum levels, urinary excretions of Zn, Cu, Fe and serum lipids in Korean rural adults on self-selected diet Lee, J.Y.;Choi, M K;Sung, C.J.
  41. J. Am. Coll Nutr. v.16 Epidimiologyc study of trace elements and magnesium on risk of coronary artety disease in rural and urban Indian populations Singh, R.B.;Gupta, U C;Mittal, N.;Niaz, M.A;Ghosh, S.;Rastogi, V.
  42. Sci. Total Environ v.204 Serum copper and zinc concentrations in serum from patients with cancer and cardiovascular disease Martin-Lagos, F.;Navarro-Alarcon, M.;Terres-Martos, C.;Lopez-G, S.H.
  43. Am. J. Clin. Nutr v.26 Hypercholesterolemia in rats produced by an increase in the ratio of zinc to copper ingested Kelvay, L.M
  44. J. Nutr. v.124 Pool size and concentration of plasma cholesterol are increased and tissue copper levels are reduced during early stages of copper deficiency in rats AL-othman, A A.;Roosenstein, F;Lei, L.Y.
  45. Kor. J Nutr. v.26 Dietary zinc analysis and changes of zinc nutrition with zinc supplementation in Korean adults Park, J.S.;Chyun, J H
  46. Kor J. Comm. Nutr. v.5 A study on the relations among zinc copper metabolism, blood glucose, insulin and serum lipids in normal adult women Kim, S R.;Sung, C.J.;Kim, M.H