한국식품영양과학회지 (Journal of the Korean Society of Food Science and Nutrition)

  • 제30권1호
  • /
  • Pages.112-118
  • /
  • 2001
  • /
  • 1226-3311(pISSN)
  • /
  • 2288-5978(eISSN)
한국식품영양과학회 (The Korean Society of Food Science and Nutrition)
권호 표지

고콜레스테롤식에서 홍화박과 들깨박이 난소절제 흰쥐의 지질대사에 미치는 영향

Effects of Defatted Safflower and Perilla Seed Powders on Lipid Metabolism in Ovariectomized Female Rats Fed High Cholesterol Diets

  • 조성희 (대구효성가톨릭대학교 식품영양학과) ;
  • 최상원 (대구효성가톨릭대하교 식품영양학과) ;
  • 최영선 (대구대학교 식품영양학과) ;
  • 이원정 (경북대학교 의과대학)
  • 발행 : 2001.02.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

To study effect of non-fat components present in plant seeds on lipid metabolism, defatted safflower and perilla seed powders were used in high cholesterol diets for ovariectomized (ovx) female Sprague-Dawley rats weighing 227$\pm$15g. Experimental groups were six as follows; normal group without ovariectomy and cholesterol-free diet, sham and ovx-control groups with high cholesterol and cellulose for dietary fiber, ovx-est group with the same diet as ovx-control but with eight subcutaneous injections of 50$\mu\textrm{g}$ 17$\beta$-estradiol. ovx-safflower and ovx-perilla with 29% and 16% (w/w) of each defatted powder in high cholesterol diets at the expense of cellulose. Weight gains were lower in normal and sham groups and food efficiencies were lower in normal,ovx-est and ovx-safflower groups compared with ovx-control. Uterus weights were dramatically reduced by ovariectomy but restored completely by 17$\beta$-estradiol and partially (~5%) by defatted safflower. Plasma levels of total cholesterol were not different among ovx-control, sham, vx-est and ovx-safflower groups (90.8~95.1 mg/dL) but that was lower in ovx-perilla (80.4$\pm$6.2 mg/dL). Plasma triglyceride (TG) levels were lower in sham (76.6$\pm$7.0 mg/dL) and ovx-perilla (79.2$\pm$5.8 mg/dL) groups. Liver cholesterol levels were lower in sham, ovx-est, ovx-safflower and ovx-perilla groups (26.6~29.8 mg/g) than ovx-control (36.5$\pm$3.2 mg/g). But liver TG levels were reduced only sham and ovx-est groups compared to control group. Fecal excretions of bile acid and cholesterol were highest in ovx-safflower group (30.8$\pm$5. and 32.1$\pm$5.7 mg/g) compared with other ovx groups (20.8~23.1 and 12.1~19.5 mg/g). These results suggest that both perilla and safflower seeds contain groups (20.8~23.1 and 12.1~19.5mg/g). These results suggest that both perilla and safflower seeds contain non-fat and non-fiber components having lipid lowering effects.

키워드

참고문헌

  1. J. Clin. Endocrinol. Metab. v.83 Clinical review 92, Phytoestrogens Murkies A. L.;Wilcox G.;Davis S. R.
  2. Proc. Natl. Acad. Sci. v.95 Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance Tikkanen M. J.;Wahala K.;Ojala S.;Vihma V.;Adlercreutz H.
  3. Nutr. Cancer. v.27 Estrogenic and antiestrogenic properties of genistein and other flavonids in human breast cancer cell in vitro Zava D. T.;Duwe G.
  4. Am. J. Clin. Nutr. v.69 Health aspects of partially defatted flaxseed, including effects on serum lipids, oxidative measures and ex vivo androgen and progestin activity Jenkins D. J. A.;Kendall C. W. C.;Vidgen E.;Agarwal W.;Ral A. V.;Rogenberg R. S.;Diamandis E. P.;Novokmet R.Mehling C. C.;Perera T.;Griffin L. C. and cunnane S.C.
  5. J. Nutr. v.128 Flaxseed and lits lignan precursor, secoisolariciresinol diglycoside, affect pregnancy outcome and reproductive development in rats Tou J. C. L.;Chen J.;Thompson L. U.
  6. Korean J. Food Sci. Technol. v.13 Antioxidant activity of ethanol extracts of defatted soybean, sesame, and perilla flours in a soybean oil-water emulsion system Kim E. H.;Kim D. H.
  7. Korean J. Food Sci. Technol. v.25 Antioxidant effects of phenolic compounds isolated from defatted perilla seed flour Lee K. Y.
  8. Korean J. Food Sci. Technol. v.25 Studies on antioxidant activity of ethanol extracts from defatted perilla flour Yoon S. K.;Kim J. H.;Kim Z. U.
  9. Korean J. Food Sci. Technol v.25 Antioxidative effect of some edible plant silvent extracts with various synergists Lee Y. J.;Shin D. W.;Chang Y. S.;Shin J. I.
  10. J. Korean Soc. Food Sci. Nutr. v.26 Fractionation of anticarcinogenic enzyme inducer(s) from roasted perilla Hong E. Y.;Kang H. J.;Suh M. J.;Nam Y. J.;Kwon C. S.;Kim J. S.
  11. J. Korean Soc. Food Nutr. v.20 Effect of the addition of defatted perilla on lipid metabolism in rats Rhie S. G.;Park Y. J.
  12. J. Nutr. v.122 Sesame seed lignans and τ-tocopherol act synergistically to produce vitamin E activity in rats Yamashita K.;Nohara Y.;Katayama K.;Namilki M.
  13. Cereal Chem. v.60 Sorghum phenoloic acids, their high performance liquid chromatography separation and their relation to fungal resistance Hahn D. H.;Faubion J. M.;Rooney L. W.
  14. Korean J. Food Sci. Technol. v.30 Screening of HMG-COA reductase inhibitory activity of ethanol and methanol extracts from cereal and legumes Ha T. Y.;Cho I. J.;Lee S. H.
  15. J. Food Sci. Nutr. v.3 Effect of methanol extract of prosomillet on cholesterol and fatty acid metabolism in rat Cho S. H.;Jung S. E.;Lee H. K.;Ha T. Y.
  16. Korean J. Oriental Med. Pathol. v.4 Study on the effects of Astragali radix, Cinnamomi ramulus and carthami flos on thrombosis and elevated blood viscosity Jung C. G.;Ahn K. S.;Moon J. J.
  17. J. Wonkang Dental Research Institute v.8 Effect of extract of seeds of carthamus tinctorius L. on mineralization in periodontal ligament cells and osteoblastic cells Kang J. K.;Shin H. S.
  18. J. Korean Soc. Food Sci. Nutr. v.27 Effects of diet of Korean safflower(carthamus tinctorious L.) seed powder on bone tissue in rats during the recovery of rib fracture Kim J. H.;Jeon S. M.;An M. Y.;Ku S. K.;Lee J. H.
  19. Agr. Chem. Biotech. v.42 Antioxidative component from the seed of Carthamus tinctorious L. Baek N. I.;Bang N. H.;Song J. C.;Lee S. Y.;Park N. K.
  20. J. Korean Soc. Food Sci. Nutr. v.28 Effects of safflower seed(carthamus tinctorious L.) powder on lipid metabolism in high pat and high cholesterolfed rats Kim J. H.;Jeon S. M.;Park Y. A.;Choi M. S.;Moon K. D.
  21. J. Nutr. v.107 Report of the American Institute of Nutrition Ad Hoc Commitee on Standars for Nutritional studies The American Institute of Nutrition
  22. M. S. Thesis The effects of Korean safflower(carthamus tinctorious L.) powder supplementation diet on the recovery of rib fracture and the improvement of lipid metabolism in rats and development of processed food Kim J. H.
  23. J. Biol. Chem. v.226 A simple method for the isolation and purification of total lipids from animal tissues Folch J.;Lees M.;Sloane-Stanley G. H.
  24. Anal. Chem. v.25 A rapid accurate method for the determination of total cholesterol in lipid extracts Pearson S.;Stern S.;Mcgavack T. H.
  25. Anal. Biochem. v.142 A sensitive enzymatic assay for determation of cholesterol in lipid extracts Sale F. O.;Marchesini S.;Fishman P. H.;Berra B.
  26. Clin. Chem. v.26 Enzymatic determination of 3α-, 7α- and 12-hydroxyl groups of fecal bile salts Crowell M. J.;Macdonald I. A.
  27. Metabolism v.46 Evidence for sex steroid inhibition of lipoprotein lipase in men;comparison of abdominal and fermonal adipose tissue Ramirez M. E.;McMurry M. P.;Wiebke G. A.;Felton K. J.;Ren K.;Meikle A. W.;Iverius P. H.
  28. J. Steroid. Biochem. v.25 Effects of 2-fluoroestradiol on lipid metabolism in the ovariectomized rat Valette A.;Meignen K. M.;Mercier L.;Liehr J. G.;Boyer J.
  29. J. Biol. Chem. v.254 Increased binding of low density lipoprotein to liver membrances from rats treated with 17 α-ethiny1 estradiol Kovanen P. T.;Brown M. S.;Goldstein J. L.
  30. Proc. Natl. Acad. Sci. v.83 Increased MRNA for low density lipoprotein receptor in livers of rabbits treated with 17 α-ethinyl estradiol Ma P. T.;Yamamoto T.;Goldsein J. L.;Brown M. S.
  31. J. Nutr. v.30 The effect of dietary lipids on CVD risk factors in ovariectomized rats Kwon J. R.;Ahn H. S.;Lee S. S.
  32. J. Pharm. Exp. Therapeutics v.28 An investigation of the relationship between estrogen. estrogen metabolities and blood cholesterol levels in ovariectomized Liu D.;Bachman K. A.
  33. J. Nutr. v.121 Brewer's spent grain, serum lipids and fecal sterol excretion in human subjects with ileostomies Zhang J. X.;Lundin E.;Anderson H.;Bosaeus I.;Dahlgren S.;Hailmans G.;Sterling R.;Aman P.
  34. J. Nutr. v.123 White wheat flour lowers plasma cholesterol and increase cecal steroids relative to whole wheat flour,wheat bran and wheat pollard in rats Illman R. J.;Storer G. B.;Topping D. L.
  35. Artery v.22 Hypolipidemic effect of Curcuma comosa in mice Piyachaturawat P.;Teeratagolpisal N.;Toskulkao C.;Suksamrarn A.