Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Protective Effects of Extracts of Diospyrus kaki Folium against Hepatotoxicity in Carbon Tetrachloride Intoxicated Rats

감잎 추출물이 사염화탄소로 유발된 흰쥐의 간손상에 미치는 효과

  • Published : 2001.02.01
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Abstract

This study was done to investigate the protective effects of Diospyrus kaki Folium on carbon tetrachloride intoxicated rats. Male Sprague-Dawley rats (200~230g) was used. Experimental groups were divided into normal group and $CCl_{4}$-treated group and then $CCl_{4}$-treated groups were divided into 7 groups: only $CCl_{4}$-treated group, methanol extract pretreated group, butanol fraction pretreated group and $H_{2}O$ fraction pretreated group, $CCl_{4}$ treated groups were injected with $CCl_{4}$ 0.6 mg/kg (ip). The activities of ananine aminotransferasein hexane, chloroform and $H_{2}O$ fraction pretreated groups were significantly decreased (p<0.05) compared to the only $CCl_{4}$-treated group and also activity of aspartate aminotransferase and hepatic malondialdehyde content in $H_{2}O$ fraction pretreated group were significantly decreased (p<0.05) compared to the only $CCl_{4}$-treated group. The activity of alkaline phosphatase in chloroform and $H_{2}O$ fraction pretreated groups were decreased compared to the only $CCl_{4}$-treated group but the difference was not statistically significant. The activity of ${\gamma}$-glutamyltranspeptidase in hexane, chloroform and ethylacetate fraction pretreated groups were significantly decreased (p<0.05) compared to the only $CCl_{4}$-treated group. The contents of cholesterol and triglyceride were not influenced in any fraction pretreated groups, but HDL-cholesterol content in hexane and chloroform fraction pretreated groups were significantly increased (p<0.05) compared to the only $CCl_{4}$-treated group. Therefore, these results demonstrate a possible hepatoprotective role of $H_{2}O$ fraction of Diospyrus kaki Folium methanol extract in carbon tetrachloride intoxicated rats.

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References

  1. Proc. Natl. Acsd. SCI. v.79 Mutagenicity of oxygen free radicals Moody C. S.;Hassan H. M.
  2. Toxicology v.41 Dose dependent study of the effects of acute lindamce administration on rat liver superoxide anion production antioxidant enzyme activities and lipid peroxidation Junqueria V. B. C.;Simiz K.;Videla L. A.;Barros S. B.
  3. J. Biol. Chem. v.259 Oxygen and carbon-centered free radical formation during carbon tetrachloride metabolism McCay P. B.;Lai E. K.;Poyer J. L.;Dubose C. M.;Janzen E. G.
  4. J. Pharmacol. Exp. Ther. v.134 Reduction of carbon tetrachloride in vivo and reduction of carbon tetrachloride and chloloform in vitro by tissues and consituents Butler T. C.
  5. J. Biol. Chem. v.261 The formation of a novel free radical metabolite from CCL₄in the perfused rat liver and vivo Connor H. D.;Thurman R. G.;Grizi M. D.
  6. Biol. Med. v.5 Free radical Hassan H. M.
  7. Ann. Rev. Nutr. v.12 Dietary carotenes, vitamin C and vitamin E as protective antioxidants in human cancers Byers T.;Perry G.
  8. 中藥大辭典 江蘇新院
  9. Sang ju national polytechnic University thesis collection v.12 Studies on the chemical constituent of permission leaf Kim J. K.;Kim K. S.
  10. J. Korean Soc. Food Nutr. v.24 The chemical composition of permission(Diospyros Kaki,Thumb) leaf tea Joung S. Y.;Lee S. J.;Sung N. J.;Jo J. S.;Kang S. K.
  11. Korean J. Food Sci Technol. v.26 Changes of components in permission leaves during growth for processing permission leaves tea Chung S. H.;Moon K. D.;Kim J. K.;Seong J. H.;Sohn T. H.
  12. Sang Ju National Polytechnic University Thesis Collection v.23 The effect of processing mthod on the quality of permission leaf tea Cha W. S.;Kim K. S.
  13. Korean J. Food Sci. Technol. v.22 The aroma components of duchung tea and permission leaf tea Choi. S. H.
  14. Korean Home Economics Association v.17 Studies on ascrobic acid contents in permission leaves tea by different cooking methods Park J. O.;Kim H. J.
  15. J. Japanese Soc. Nutr. Food Sci. v.44 The relationship between Vitamin C and polyphenol content in permission leaves Naoko S.;Keiko L.
  16. Ph. D. Thesis The natural removal of astringency in sweet permission fruit and distribution of tannin substance Seong J. H.
  17. Agric. Biol. Chem. v.42 The chemical structure of Kaki tannin from immature fruit of the permission Matsou T.;Ito S.
  18. Chem. Pharm. Bull. v.38 Prolongation of life span of stroke-prone spontaneosly hypertensive rats(SHRSP)ingesting permission tannin Uchida S.;Ochta H.;Niwa M.;Mori A.;Nanaka G.;Nishioka I.;Ozaki M.
  19. Food and Biotech v.5 Antioxidative activity of flavonoids in permission leaves Choi S. W.;Kang W. W.
  20. J. Korean Soc. Food Nutr. v.22 Antimutagenic effects and compounds identified from hexane fraction of permission leaves Moon S. H.;Kim J. O.;Rhee S. H.;Park K. Y.;Kim K. H.;Rhew T. H.
  21. J. Food Sci. Nutr. v.1 Antimugenic compounds identified from chloroform fraction of permission leaves Moon S. H.;kim J. O.;Park K. Y.
  22. J. Korean Soc. Food. Nutr. v.25 Antimugenic effects of persimmon leaf ten extracts in sister chromatidex change(SCE) assay system Song H. S.;Lee H. K.;Jang H. D.;Kim J. I.;Park O. J.;Lee M. S.;Kang M. H.
  23. J. Korean Soc. Food Nutr. v.25 Antitumor effect persimmon leaves in vivo using sarcoma 180 cells Moon S. H.;Kim K. H.;Park K. Y.
  24. J. Korean Soc. Food Sci. Nutr. v.29 Effect of polyphenol compounds from persimmon leaves on allergic contact dermatitis Park M. H.;Cheong C.;Bae M. J.
  25. J. Korean Soc. Food Sci. Nutr. v.29 Effect of Polyphenol compounds from persimmon leaves on antiallergy Park M. H.;Choi C. C.;Son G. M.;Bong J. A.;Bae M. J.
  26. J. Korean Soc. Food Sci. Nutr. v.29 Effect of persimmon leaves extract on serum and liver concentration in hypercholesterolemic rats Park J. Y.;Park E. M.;Lee M. K.;Jang J. Y.;kim M. J.;Cho S. Y.
  27. Toxicol. Pathol. v.19 Colchicine antimiosis abolishes CCl₄autoprotection Rao V. C.;Nehendale H. M.
  28. Am. J. Clin. Pathol. v.28 A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase Reitman S.;Frankel S.
  29. Sangyo Igaku v.24 Investigation on physiological values of blood in industrial workers, Report 2. Serum Colloid reaction and enzyme activity values Kawano S.;Nakagawa H.;Toga H.
  30. Chin. Chem. v.16 A kinetic photometric method for serum τ-glutamyltrans peptidase Szaz G
  31. Clin. Chem. v.18 Effect of hydrogen ion cencentration on lactate dehydrogenase(LDH)assays King J.
  32. Clinical chemistry v.26 Mechanism of unterference by hemoglobin in the determination of total bilirubin 1. Method of Malloy-Evelyn Bruce C.;Shull H. L.;Philip K. L.
  33. J. Lipid Res. v.32 A Microenzymatic method to measure cholesterol and triglyceride in lipoprotein subfractions seperated by density gladient ultracentrifugation from 200 microliters of plasma or serum Belcher J. D.;Egan J. O.;
  34. Anal. Biochem. v.86 Determination of malondialdehyde percursor in tissues by thiobarbituric acid test Uchiyama M.;Mihara M.
  35. Brit. Med. J. v.3 Effect of onions on blood fibrinoitic activity Menson I. S.;Kendal R. Y.;Dewae H. A.;Newel D. J.
  36. Principles and methods of toxicology Hayes
  37. Clinical interpretation of lavoratory tests(9th ed.) Widman F. K.
  38. Folia Pharmacol. Japan v.85 Pharmacological studies on schizandra fruits. ⅲ. Effects of wuweizisu C, a ligan component of schixanda fruits, on experimental liver injuries in rats Takeda S.;Funo S.;IIzuka A.;Kase Y.;Arai I.;Ohkura Y.;Sudo K.;Kiuchi N.;Yoshida C.;Maeda S.;Abrada M.;Hosoya E.
  39. Biochim. Biophys. v.795 The critical steady state hypoxic condition in carbon tetrachloride induced lipid peroxidation in rat liver microsomes Noll T.;Groot H.