Journal of Gastric Cancer

The Korean Gastric Cancer Association (대한위암학회)
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Study of the Expression of FasL and of Apoptosis in Gastric Epithelial Dysplasia and Gastric Adenocarcinomas

위상피이형성과 위암종에서 FasL의 발현 및 Apoptosis에 관한 연구

  • Park Gun Uk (Departments of Internal Medicine, Dong-A University Medical School) ;
  • Han Sang Young (Departments of Internal Medicine, Dong-A University Medical School) ;
  • Lee Jong Hun (Departments of Internal Medicine, Dong-A University Medical School) ;
  • Keum Dong Joo (Departments of Internal Medicine, Dong-A University Medical School) ;
  • Roh Myung Hwan (Departments of Internal Medicine, Dong-A University Medical School) ;
  • Choi Seok Ryeol (Departments of Internal Medicine, Dong-A University Medical School) ;
  • Kim Jong Seong (Departments of Internal Medicine, Dong-A University Medical School) ;
  • Roh Mee Sook (Departments of Anatomic Pathology,Dong-A University Medical School,)
  • 박건욱 (동아대학교 의과대학 내과학교실) ;
  • 한상영 (동아대학교 의과대학 내과학교실) ;
  • 이종훈 (동아대학교 의과대학 내과학교실) ;
  • 금동주 (동아대학교 의과대학 내과학교실) ;
  • 노명환 (동아대학교 의과대학 내과학교실) ;
  • 최석렬 (동아대학교 의과대학 내과학교실) ;
  • 김종성 (동아대학교 의과대학 내과학교실) ;
  • 노미숙 (동아대학교 의과대학 해부병리학교실)
  • Published : 2001.06.01
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Abstract

Purpose: This study was to observe whether the apoptotic function of tumor-infiltrating lymphocytes (TIL) is induced in human gastric epithelial dysplasia and gastric adenocarcinoma according to the role of FasL expression. Materials and Methods: A total of 56 gastric epithelial dysplasia and gastric adenocarcinoma patients were enrolled in this study: 9 cases of gastric epithelial dysplasia, 18 cases of early gastric carcinomas (EGC) and 29 cases of advanced gastric carcinomas (AGC). Immunohistochemical staining was performed for FasL and CD45, and the terminal deoxynucleotidyl transferase mediated dUTP nick end labelling (TUNEL) method was used to detect cell death in tumor-infiltrating lymphocytes. Results: 1) Positive reactions of FasL to neoplastic cells were $88.9\%$ (8/9) in gastric epithelial dysplasia, $83.3\%$ (15/18) in EGC, and $75.9\%$ (22/29) in AGC. 2) Expression of TIL was decreased in the FasL positive region and was increased in the FasL negative region, and significant expression of TIL was observed in the AGC group (P=0.001). 3) Expression of apoptotic TIL was very similar to the FasL expression, and $100\%$ expression was observed in gastric epithelial dysplasia group. 4) Expression of apoptotic TIL was increased in the FasL positive region and decreased in the FasL negative region, and significant apoptotic expression was observed in the gastric epithelial dysplasia and EGC groups (P=0.0420, P=0.0263, respectively). Conclusion: These results suggest that FasL is a prevalent mediator of immune privilege in epithelial dysplasia and cancer of the stomach.

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