Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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Effects of Boyikcheungnoy-tang (BYCNT) on inhibition of impairment of learning and memory, and acetylcholinesterase in amnesia mice

보익청뇌탕(補益淸腦湯)이 치매병태(痴?病態) 모델에 미치는 영향(影響)

  • Lee Sang-Ryong (Department of Neuropsychiatry, College of Oriental Medicine, Dae Jeon University) ;
  • Koh Tae-Joon (Department of Neuropsychiatry, College of Oriental Medicine, Dae Jeon University)
  • 이상룡 (대전대학교 한의과대학 신경정신과 교실) ;
  • 고태준 (대전대학교 한의과대학 신경정신과 교실)
  • Published : 2001.06.30
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Abstract

Alzheimer's disease(AD) is a progressive neurodegenerative disease, which is pathologically characterized by neuritic plaques and neurofibrillary tangles associated with the acetylchohnesterase, apolipoprotein E and butylcholinesterase, and by mutations in the presenilin genes PS1 and PS2, and amyloid precursor proteins (APPs)'s overexpression. The present research is to examine the inhibition effect of BYCNT on PS-1, PS-2 and APPs's overexpression by detected to Western blotting. To verify the effects of BYCNT on cognitive deficits further, we tested it on the scopolamine(1mg/kg)-induced amnesia model of the mice using the Morris water maze tests, and there was ameliorative effects of memory impairment as a protection from scopolamine. BYCNT only partially blocked the increase in blood serum level of acetylcholinesterase and Uric acid induced by scopolamine, whereas blood glucose level was shown to attenuate the amnesia induced by scopolamine and inreased extracellular serum level compared with only scopolamine injection. In conclusion, studies of BYCNT that has been known as anti-choline and inhibition ablilities of APPs overexpression, this could also be used further as a important research data for a preventive and promising symptomatic treatment for Alzheimer's disease.

Keywords

References

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