대한한방소아과학회지 (The Journal of Pediatrics of Korean Medicine)

  • 제15권2호
  • /
  • Pages.15-30
  • /
  • 2001
  • /
  • 1226-8038(pISSN)
  • /
  • 2287-9463(eISSN)
대한한방소아과학회 (The Association of Korean Oriental Pediatrics)
권호 표지

보중익기탕가미(補中益氣湯加味)가 새끼 생쥐의 면역능(免疫能)에 미치는 영향(影響)

Effect of Bojung-Ikgi-Tang-Gami(BITG) on Immune Response in the Young Mice

  • 박지수 (대전대학교 한의과 대학원 소아과) ;
  • 김윤희 (대전대학교 한의과대학 소아과) ;
  • 류동열 (대전대학교 한의과대학)
  • Park Jee-Su (Dept. of Oriental Medicine Graduate School, DaeJeon University) ;
  • Kim Yun-Hee (Dept. of Oriental Medicine Graduate School, DaeJeon University) ;
  • Yoo Dong-Youl (Dept. of Oriental Medicine Graduate School, DaeJeon University)
  • 발행 : 2001.12.15
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초록

The purpose of this research was to investigate the effects of BITG on immune response in the young mice. BITG(500mg/kg) was administerd per orally once a day for 7 days to the young BALB/C(4 wks old)mice. The administrationo of BITG enhanced the cell viability of splenocytes, but did not affect that of thymocytes. In vitro system, BITG decreased the cell viability of thymocytes and splenocytes at the concentration of $100{\mu}g/m{\ell}$. The administration of BITG did not affect DNA fragmentation of thymocytes, but decreased that of splenocytes. The administration of BITG increased the population of Thy1+ cell and CD4+CD8- cell in splenocytes. In addition, BITG decreased the production of NO and increased the lucigenin chemiluminescence from peritoneal macrophages. These results suggest that BITG enhances the specific-immune and nonspecific-immune response via increase of cell viability in splenocytes and of phagocytic activity in peritoneal macrophages.

키워드

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