Journal of the Korean Association of Oral and Maxillofacial Surgeons
- 제27권4호
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- Pages.281-288
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- 2001
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- 2234-7550(pISSN)
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- 2234-5930(eISSN)
소목 추출물의 구강암 및 골육종 세포주에 대한 항암작용에 관한 연구
STUDIES ON ANTICANCER EFFECTS OF EXTRACTS CAESALPINIA SAPPAN ON ORAL CARCINOMA AND OSTEOSARCOMA CELLS
- Lee, Jong-Su (Department of Oral and Maxillofacial Surgery, College of Dentistry, Kyung-Hee University) ;
- Kim, Yeo-Gab (Department of Oral and Maxillofacial Surgery, College of Dentistry, Kyung-Hee University) ;
- Kim, Jeong-Hee (Lab. of Oral Biochemistry, College of Dentistry, Kyung-Hee University)
- 발행 : 2001.08.31
초록
Anticancer effect of methanol extract of Caesalpinia sappan L. on oral carcinoma (KB) and osteosarcoma (HOS) cells were investigated in this study. In order to elucidate the anticancer mechanism of Caesalpinia sappan L, we analyzed telomerase inhibitory effect of the methanol extract of Caesalpinia sappan L. In addition we prepared 5 fraction samples according to its polarity differences and analyzed anticancer effects on oral carcinoma and osteosarcoma cells. Following results are obtained in this study. 1. 50% cell proliferation inhibitory value (