Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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THE EFFECTS OF LOW INTENSITY-ULTRASOUND ON THE ACTIVITY OF MC3T3-E1 CELL IN VITRO

저강도 초음파 조사시 MC3T3-E1 세포의 활성에 미치는 영향

  • Choi, You-Sung (Department of Oral & Maxillofacial Surgery, College of Dentistry, Kyung-Hee University) ;
  • Lee, Sang-Chull (Department of Oral & Maxillofacial Surgery, College of Dentistry, Kyung-Hee University)
  • 최유성 (경희대학교 치과대학 구강악안면외과학교실) ;
  • 이상철 (경희대학교 치과대학 구강악안면외과학교실)
  • Published : 2001.04.30
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Abstract

This study was performed to observe the effect of ultrasound(1.0MHz, $0.75W/cm^2\;and\;1.0W/cm^2$) irradiation on cultured MC3T3-E1 cell, osteoblastic like cell with respect to the proliferation, protein synthesis, and alkaline phosphatase activity of the cells. The results were as follows: 1. The proliferation of MC3T3-E1 cells was increased on ultrasound irradiated group compared with control group. 2. The protein synthesis was not apparently increased on ultrasound irradiated group compared with control group. 3. The alkaline phosphatase activity level was not apparently increased on ultrasound irradiated group compared with control group. From the above results and other literatures, we could suggest that the ultrasound with the appropriate intensity and frequency may have important roles in stimulation of cell proliferation. Therefore the ultrasound may be used in the acceleration of the bone regeneration and bone fracture healing.

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