Journal of Pharmaceutical Investigation
- Volume 31 Issue 2
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- Pages.81-87
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- 2001
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Effect of Additives on the Powder Characteristics of Peonja Dry Elixir
편자 고형엘릭실제의 분체 특성에 미치는 부형제의 영향
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Yong, Chul-Soon
(College of Pharmacy, Yeungnam University) ;
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Lee, Jong-Dal
(College of Pharmacy, Yeungnam University) ;
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Kim, Chong-Kook
(College of Pharmacy, Seoul National University) ;
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Choi, Han-Gon
(College of Pharmacy, Yeungnam University)
- Published : 2001.06.20
Abstract
The purpose of this study was to investigate the effect of additives on the powder characteristics of peonja dry elixir. Peonja dry elixirs were prepared with various amounts of dextrin using a spray-dryer, and their powder characteristics such as flow, cohesion and compressibility were evaluated as an angle of repose, cohesion index and compressibility index, respectively. Their powder characteristics were not significantly different from one another, indicating that the hydrophilic dextrin, a base of dry elixir hardly affected their powder characteristics. Peonja dry elixirs were prepared with 10% dextrin and various amounts of additives such as mannitol (hydrophilic excipient), sodium lauryl sulfate (surfactant), colloidal silica (hydrophobic excipient) and HPMC (polymer), respectively, and their angle of repose, cohesion index and compressibility index were measured. The powder characteristics of peonja dry elixirs prepared with mannitol were not significantly different from one another, indicating that the mannitol scarcely improved the powder characteristics of peonja dry elixirs. The angle of repose and cohesion index of peonja dry elixirs significantly decreased with increasing amount of sodium lauryl sulfate to 0.3% followed by no significant changes in them. The cohesion index of peonja dry elixir significantly decreased with increasing amount of colloidal silica. The angle of repose and cohesion index of peonja dry elixir significantly decreased with increasing amount of HPMC to 0.3% followed by an abrupt increase in them. However, the compressibility index of peonja dry elixir significantly increased with increasing amount of HPMC to 0.3% followed by an abrupt decrease in them. Our results suggested that a small amount of sodium lauryl sulfate, colloidal silica and HPMC improved markedly the powder characteristics of peonja dry elixirs due to forming stronger and less hygroscopic shell of peonja dry elixirs. Among the peonja dry elixirs studied, the peonja dry elixir prepared with 0.3% sodium lauryl sulfate and 0.3% HPMC had the lowest angle of repose of