Journal of Pharmaceutical Investigation
- 제31권1호
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- Pages.1-5
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- 2001
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
니스타틴의 응집 특성 및 용혈 활성
The Aggregation State and Hemolytic Activity of Nystatin
- 유봉규 (위스콘신-메디슨 대학교 약학대학)
- Yu, Bong-G. (School of Pharmacy, University of Wisconsin-Madison)
- 발행 : 2001.03.20
초록
The aggregation behavior of nystatin (NYS) in the presence of pluronic F127, triblock copolymer of poly (ethylene oxide) (PEO) and poly (propylene oxide) (PPO), was measured and correlated with hemolytic activity. Antifungal activity was also studied using Saccharomyces cerevisiae as a model strain. The critical aggregation concentrations (CAC) of the drug were 50.1, 108.0, 134.2, 154.3, and
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