생약학회지 (Korean Journal of Pharmacognosy)
- 제32권4호통권127호
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- Pages.280-286
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- 2001
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Epigallocatechin-3-gallate의 사람 비점막 섬유아세포 케모카인발현에 대한 효과
Effect of Epigallocatechin-3-gallate on Expression of Chemokines in Human Nasal Mucosal Fibroblasts
- Cho, Jeong-Je (College of Medicine, Kyung Hee University) ;
- Leem, Kang-Hyun (College of Pharmacy, Woosuk University)
- 발행 : 2001.12.30
초록
Epigallocathechin-3-gallate (EGCG), the main polyphenol component in green tea, inhibits angiogenesis, urokinase, and matalloproteinases, and EGCG also has the antioxidative property. Recent reports proposed that EGCG may modulate the immune response on allergy or asthma. Human nasal mucosal fibroblasts are a rich source of cytokines, inflammatory mediators, and chemokines. Chemokines are important for the recruitment of leukocytes to sites of infection, which is essential in host defense. The objective of this study was to investigate the effect of EGCG on the expression of the chemokines such as RANTES (regulated upon activation, normal T cell expressed and presumably secreted), eotaxin, and interleukin-8 (IL-8) in human nasal mucosal fibroblasts after stimulation with cytokines like IL-4, tumor necrosis