생약학회지 (Korean Journal of Pharmacognosy)
- 제32권4호통권127호
- /
- Pages.297-301
- /
- 2001
- /
- 0253-3073(pISSN)
- /
- 2288-9299(eISSN)
Compound 48/80 유도 즉시형 과민반응에 대한 뱀차즈기의 억제효과
Inhibitory Effect of Salvia plebeia on Compound 48/80-Induced Immediate Hypersensitivity Reaction
- 최용길 (우석대학교 약학대학) ;
-
김상현
(조지아대학교 약리 및 독성학부)
;
-
임종필
(우석대학교 약학대학)
;
- 김대근 (우석대학교 약학대학) ;
- 엄동옥 (우석대학교 약학대학) ;
-
이경보
(우석대학교 약학대학)
;
-
김상용
(전북대학교 농과대학)
;
- 신태용 (우석대학교 약학대학)
- Choi, Yong-Gil (College of Pharmacy, Woosuk University) ;
-
Kim, Sang-Hyun
(Department of Pharmacology and Toxicology, University of Georgia)
;
-
Lim, Jong-Pil
(College of Pharmacy, Woosuk University)
;
- Kim, Dae-Keun (College of Pharmacy, Woosuk University) ;
- Eom, Dong-Ok (College of Pharmacy, Woosuk University) ;
-
Lee, Kyeong-Bo
(College of Pharmacy, Woosuk University)
;
-
Kim, Sang-Yong
(College of Agriculture, Chonbuk National University)
;
- Shin, Tae-Yong (College of Pharmacy, Woosuk University)
- 발행 : 2001.12.30
초록
We studied the inhibitory effect of the aqueous extract of Salvia plebeia (SPAE) on immediate hypersensitivity reactions. SPAE inhibited immediate hypersensitivity reaction induced by compound 48/80 in mice. When SPAE was employed in an immediate hypersensitivity reaction test, the plasma histamine levels were reduced in a dose-dependent manner. SPAE also inhibited the histamine release from rat peritoneal mast cells (RPMC) by compound 48/80. The level of cAMP in RPMC, when SPAE was added, significantly increased compared with that of a normal control. These results indicate that SPAE may be beneficial in the treatment of immediate hypersensitivity reactions.
키워드