생약학회지 (Korean Journal of Pharmacognosy)
- 제32권4호통권127호
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- Pages.311-315
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- 2001
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
황기의 COX-2 활성 억제 효과
Inhibitory effect of Astragali Radix on COX-2 activity
- Kim, Eun-Jeong (College of Pharmacy, Sookmyung Women's University) ;
- Oh, O-Jin (College of Pharmacy, Ewha Womans University) ;
- Lee, Sang-Kook (College of Pharmacy, Ewha Womans University) ;
- Yang, Ki-Sook (College of Pharmacy, Sookmyung Women's University)
- 발행 : 2001.12.30
초록
The root of Astragalus membranaceus Bunge (Leguminosae), which has been used for the treatment of hypertension, chronic hepatitis, duodenal ulcers, chronic nephritis and promotion of immunity in folk remedies. Cyclooxygenase (COX-2) is responsible for the production of large amounts of proinflammatory prostaglandins (PGs) at the inflammatory site. Thus, a logical approach to the treatment of inflammatory disease should involve the inhibitors of COX-2. To develop new COX-2 inhibitors from natural products, Astragali Radix was screened by inhibiting prostaglandin
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