생약학회지 (Korean Journal of Pharmacognosy)
- 제32권3호통권126호
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- Pages.226-232
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- 2001
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
보양환오탕에 의한 비특이적 세포독성 T 세포 활성 증강
Promotion of Nonspecific Cytotoxic T Lymphocyte Activity by Bo-yang-hwan-oh-tang
- Ha, Jong-Cheon (Department of Microbiology, School of Natural Science, Jeonju University) ;
- Kim, Young-Hyun (Department of Microbiology, School of Natural Science, Jeonju University) ;
- Woo, Won-Hong (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
- Nam, Sang-Yun (Department of Microbiology, School of Natural Science, Jeonju University)
- 발행 : 2001.09.30
초록
To explore the possible cancer therapeutic application of "Bo-yang-hwan-oh-tang" (BH), a herbal medicinal recipe used for improvement of blood stasis, we have examined its direct cytotoxicity against tumor cell, and induction of cytotoxic activity of lymphocytes. Water extract of BH alone did not exhibit direct cytotoxicity to Yac-1 target cells even with high concentrations (10 mg/ml). By exposure for 3 days, BH did not induce any nonspecific cytotoxic activity of mouse spleen cells, either, when assessed in a 4 hr