생약학회지 (Korean Journal of Pharmacognosy)
- 제32권2호통권125호
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- Pages.103-107
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- 2001
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
가시오갈피 줄기의 물 추출물이 지질대사에 미치는 영향
Effects of the Water Extract from the Stem Bark of Acanthopanax senticosus on Hyperlipidemia in Rats
- 이연실 (서울대학교 천연물과학연구소) ;
- 정상훈 (서울대학교 천연물과학연구소) ;
- 임순성 (서울대학교 천연물과학연구소) ;
- 지준 (서울대학교 천연물과학연구소) ;
- 이상현 (서울대학교 천연물과학연구소) ;
- 신국현 (서울대학교 천연물과학연구소)
- Lee, Yeon-Sil (Natural Products Research Institute, Seoul National University) ;
- Jung, Sang-Hoon (Natural Products Research Institute, Seoul National University) ;
- Lim, Soon-Sung (Natural Products Research Institute, Seoul National University) ;
- Ji, Jun (Natural Products Research Institute, Seoul National University) ;
- Lee, Sang-Hyun (Natural Products Research Institute, Seoul National University) ;
- Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University)
- 발행 : 2001.06.30
초록
The effects of the water extract from the stem bark of Acanthopanax senticosus were evaluated on hyperlipidemic rats induced by lipid rich diet or poloxamer-407. The water extracts, when administered orally for 3 consecutive days in hyperlipidemic rats induced by poloxamer-407 (1 ml of 30%), was found to cause a significant decrease in plasma cholesterol and triglyceride concentrations. The water extracts, when treated orally for 5 consecutive days also showed a significant inhibition of serum total cholesterol and triglyceride level in rats treated with lipid rich diet (15% cholesterol, 1% sodium cholate and 84% com oil). HDL-cholesterol, however, was increased significantly.
키워드