The Effect of Opuntia ficus-indica var. saboten Fruit on Gastric Lesion and Ulcer in Rats

  • Lee, Eun-Bang (Natural Products Research Institute, Seoul National University) ;
  • Hyun, Jin-Ee (Natural Products Research Institute, Seoul National University) ;
  • Li, Da-Wei (Natural Products Research Institute, Seoul National University) ;
  • Moon, Yung-In (Pukjeju Agricultural Development and Technology Extension Center)
  • Published : 2001.09.01

Abstract

The effects of the dried fruit powder of Opuntia ficus-indica var. saboten (OF-f) were investigated on gastric lesion and ulcer models in rats. It showed significant inhibition in HCl ethanol and HCl aspirin induced gastric lesion at a dose of 600 mg/kg, p.o. OF-f also showed significant inhibition in indomethacin induced gastric lesion at the doses of 200 and 600 mg/kg, p.o. However, it did not affect aspirin and Shay ulcer in rats. It also did not affect the gastric juice secretion, acid output and pH. These data suggest that OF-f possesses pronounced inhibitory action on gastric lesion of rats.

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