The Korean Journal of Physiology and Pharmacology
- Volume 5 Issue 6
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- Pages.521-527
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- 2001
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Diclofenac Inhibits $IFN-{\gamma}$ Plus Lipopolysaccharide-Induced iNOS Gene Expression via Suppression of $NF-{\kappa}B$ Activation in RAW 264.7 Macrophages
- Bae, So-Hyun (Department of Pharmacology, College of Medicine, Chungnam National University) ;
- Ryu, Young-Sue (Department of Pharmacology, College of Medicine, Chungnam National University) ;
- Hong, Jang-Hee (Department of Pharmacology, College of Medicine, Chungnam National University) ;
- Park, Jin-Chan (Department of Pharmacology, College of Medicine, Chungnam National University) ;
- Kim, Yong-Man (Genetic Pharmacology Unit, National Institute of Neurological Disorders and Stroke) ;
- Seok, Jeong-Ho (Department of Pharmacology, College of Medicine, Chungnam National University) ;
- Lee, Jae-Heun (Department of Pharmacology, College of Medicine, Chungnam National University) ;
- Hur, Gang-Min (Department of Pharmacology, College of Medicine, Chungnam National University)
- Published : 2001.12.21
Abstract
Diclofenac, a phenylacetic acid derivative, is a widely used non-steroidal anti-inflammatory drug (NSAID) to provide effective relief of inflammation and pain. Nitric oxide (NO) synthesized by inducible nitric oxide synthase (iNOS) has been implicated as a mediator of inflammation. We examined the inhibitory effects of diclofenac on the induction of iNOS in RAW 264.7 macrophages which were activated with lipopolysaccharide (LPS) plus interferon-gamma