The Korean Journal of Physiology and Pharmacology
- 제5권1호
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- Pages.93-98
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- 2001
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
The Hyperthermic Effect of Nitric Oxide in Central Nervous System
- Jung, Jae-Kyung (Lab of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
- Sohn, Uy-Dong (Lab of Pharmacology, College of Pharmacy, Choong-Ang University) ;
- Lee, Seok-Yong (Lab of Pharmacology, College of Pharmacy, Sungkyunkwan University)
- 발행 : 2001.02.21
초록
The precise mechanism of set-point regulation in hypothalamus was not elucidated. Nitric oxide synthases(NOS) were detected in hypothalamus, however, the roles of NO in hypothalamus was not fully studied. So, we tested the effects of NO on body temperature because preoptic-anterior hypothalamus was known as the presumptive primary fever-producing site. NO donor sodium nitroprusside (SNP, 4 nmol, i.c.v.) elicited marked febrile response, and this febrile response was completely blocked by indomethacin (a cyclooxygenase inhibitor). But, ODQ (selective guanylate cyclase inhibitor,