The Korean Journal of Physiology and Pharmacology
- 제5권1호
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- Pages.47-53
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- 2001
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Pulse Exposure to Ethanol Augments Vascular Contractility Through Stress Response
- Yang, Eun-Kyoung (Department of Physiology, Kyungpook National University School of Medicine) ;
- Kim, In-Kyeom (Department of Pharmacology, Kyungpook National University School of Medicine)
- 발행 : 2001.02.21
초록
Drinking excessive alcohol has been recognized as a risk factor for hypertension. However, the mechanism by which alcohol intake causes hypertension still remains elusive. We tested the hypothesis that ethanol itself acts as a stress factor on vasculature and indirectly modulates vascular contractility. After end of exposure to 1, 2.5 and 5% ethanol for 45 min, rat aortic strips were subjected to contractile responses, immunoblot for Hsp70 and the measurement of levels of myosin light chain phosphorylation. Exposure to 5% ethanol not only augmented contractions to KCl or phenylephrine, but also increased expression of Hsp70 and the levels of myosin light chain phosphorylation. There were no significant differences in contractions produced by