Bioequivalence Study of a Generic Aceclofenac Tablet Preparation

Aceclofenac 경구제제인 에이서정의 생물학적동등성에 관한 연구

  • Kim, Dong-Hyun (Center for Drug Metabolism, KIST) ;
  • Shin, Kyung-Sue (Department of Pediatrics, Cheju National University Hospital) ;
  • Sohn, Dong-Ryul (Department of Clinical Pharmacology, Soonchunhyang University College of Medicine)
  • 김동현 (한국과학기술원 생체대사연구소) ;
  • 신경수 (제주대학교병원 소아과) ;
  • 손동렬 (순천향대학교 의과대학 임상약리학교실)
  • Published : 2001.12.30

Abstract

Background : The bioavailability of a generic preparation of aceclofenac(Acer from Kyungdong Pharmaceutical Company) was evaluated in comparison with a proprietary product(Airtal from Daewoong Pharmaceutical Company). Methods : Sixteen healthy male volunteers participated in the study conducted according to a two-way crossover, open-labeled Latin square design. The bioavailability was compared using the parameters total area under the plasma concentration-time curve$(AUC_{0-{\infty}})$, peak plasma concentration$(C_{max})$ and time to reach peak plasma concentration$(T_{max})$. Results : No statiscally significant difference was observed between the values of the two products in all three parameters. Moreover, the 90% confidence interval for the ratio of the logarithmic-transformed $AUC_{0-{\infty}}\;and\;C_{max}$ values of Acer over those of Airtal was found to lie between 0.94-1.03 and 0.94-1.06, respectively, being within the acceptable bioequivalence limit of 0.80-1.25. Conclusion : These findings indicate that the two preparations are comparable in the extent and rate of absorption.

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