한방안이비인후피부과학회지 (The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology)
- 제13권2호
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- Pages.211-220
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- 2000
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- 1738-6640(pISSN)
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- 2234-4020(eISSN)
Shini-San Inhibits Mast Cell-Dependent Immediate-Type Allergic Reactions
- Kim, H.M. (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
- Lee, Y.H. (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
- Chae, H.J. (Department of Dental Pharmacology, School of Dentistry, Wonkwang University) ;
- Kim, H.R. (Department of Dental Pharmacology, School of Dentistry, Wonkwang University) ;
- Baek, S.H. (Division of Chemistry, Technical and Biological Science, College of Natural Sciences, Wonkwang University) ;
- Lim, K.S. (College of Oriental Medicine, Center of Oriental Medicinal Science, Wonkwang University) ;
- Hwang, C.Y. (College of Oriental Medicine, Center of Oriental Medicinal Science, Wonkwang University)
- 발행 : 20000900
초록
Shini-San has been used for treatment of allergic disease in Korea. However, its effect in experimental models remains unknown. The mast cell plays a pivotal role in initiating al1ergic response by secreting intracytoplasmic granular mediators such as histamine. The present report describes an inhibitory effect of Shini-San on mast cell-mediated immediate-type al1ergic reactions. Topical application of compound 48/80 can induce an ear swelling response in normal (
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