생물정신의학 (Korean Journal of Biological Psychiatry)
- 제7권1호
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- Pages.21-33
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- 2000
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- 1225-8709(pISSN)
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- 2005-7571(eISSN)
항우울제와 연관약물의 약물상호작용
Antidepressants and Related Drug Interactions
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이민수
(고려대학교 의과대학 신경정신과학교실)
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Lee, Min Soo
(Department of Neuropsychiatry, Korea University College of Medicine)
- 발행 : 2000.06.30
초록
As the clinical practice of using more than one drug at a time increase, the clinician is faced with ever-increasing number of potential drug interactions. Although many interactions have little clinical significances, some may interfere with treatment or even be life-threatening. This review provides a better understanding of drug-drug interactions often encountered in pharmacotherapy of depression. Drug interactions can be grouped into two principal subdivisions : pharmacokinetic and pharmacodynamic. These subgroups serve to focus attention on possible sites of interaction as a drug moves from the site of administration and absorption to its site of action. Pharmacokinetic processes are those that include transport to and from the receptor site and consist of absorption, distribution on body tissue, plasma protein binding, metabolism, and excretion. Pharmacodynamic interactions occur at biologically active sites. In this review, emphasis is placed on antidepressant medications, how they are metabolized by the P450 system, and how they alter the metabolism of other drugs. When prescribing antidepressant medications, the clinician must consider the drug-drug interactions that are potentially problematic.