BMB Reports
- 제33권6호
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- Pages.541-547
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- 2000
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- 1976-670X(eISSN)
Transbilayer Effects of Chlorpromazine.HCl on Rotational Mobility of Synaptosomal Plasma Membrane Vesicles Isolated from Bovine Brain
- Ahn, Ki-Weon (Department of Dental Pharmacology and Biophysics, College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University) ;
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Choi, Chang-Hwa
(Department of Neurosurgery, College of Medicine and Research Institute for Oral Biotechnology, Pusan National University) ;
- Kim, Inn-Se (Department of Anesthesiology, College of Medicine and Research Institute for Oral Biotechnology, Pusan National University) ;
- Chung, In-Kyo (Department of Oral and Maxillofacial Surgery and Clinical Phannacology, College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University) ;
- Cho, Goon-Jae (Department of Internal Medicine, College of Medicine and Research Institute for Oral Biotechnology, Pusan National University) ;
- Jang, Hye-Ock (Department of Oriental Pathology and Prescription, College of Oriental Medicine, Dong-Eui University) ;
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Yun, Il
(Department of Dental Pharmacology and Biophysics, College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University)
- 투고 : 2000.10.10
- 심사 : 2000.11.09
- 발행 : 2000.11.30
초록
Fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene (DPH) was used to evaluate the effects of chlorpromazine HCl on the range of the rotational mobility of bulk bilayer structure of the synaptosomal plasma membrane vesicles (SPMV) isolated from a bovine brain. In a dose-dependent manner, chlorpromazine HCl increased the anisotropy (r), limiting anisotropy (