BMB Reports
- 제33권5호
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- Pages.379-384
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- 2000
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- 1976-670X(eISSN)
Conformational Switch of the Strained Native Serpin Induced by Chemical Cleavage of the Reactive Center Loop
- Im, Ha-Na (Department of Molecular Biology, Sejong University) ;
- Yu, Myeong-Hee (National Creative Research Initiative Center, Korea Institute of Science and Technology)
- 투고 : 2000.06.05
- 심사 : 2000.08.04
- 발행 : 2000.09.30
초록
The native conformation of serpins (serine protease inhibitors) is strained. Upon cleavage of the reactive center loop of serpins by a protease, the amino terminal portion of the cleaved loop is inserted into the central