BMB Reports
- 제33권4호
- /
- Pages.317-320
- /
- 2000
- /
- 1976-670X(eISSN)
Brain Succinic Semialdehyde Dehydrogenase; Reaction of Arginine Residues Connected with Catalytic Activities
- Bahn, Jae-Hoon (Department of Genetic Engineering, Division of Life Sciences, Hallym University) ;
- Lee, Byung-Ryong (Department of Genetic Engineering, Division of Life Sciences, Hallym University) ;
- Jeon, Seong-Gyu (Department of Genetic Engineering, Division of Life Sciences, Hallym University) ;
- Jang, Joong-Sik (Department of Genetic Engineering, Division of Life Sciences, Hallym University) ;
- Kim, Chung-Kwon (Graduate Program of Aging, Division of Life Sciences, Hallym University) ;
- Jin, Li-Hua (Graduate Program of Aging, Division of Life Sciences, Hallym University) ;
- Park, Jin-Seu (Department of Genetic Engineering, Division of Life Sciences, Hallym University) ;
- Cho, Yong-Joon (Department of Neurosurgery, College of Medicine, Hallym University) ;
- Cho, Sung-Woo (Department of Biochemistry, College of Medicine University of Ulsan) ;
- Kwon, Oh-Shin (Department of Biochemistry, College of Natural Sciences, Kyungpook National University) ;
- Choi, Soo-Young (Department of Genetic Engineering, Division of Life Sciences, Hallym University)
- 투고 : 2000.04.26
- 심사 : 2000.05.29
- 발행 : 2000.07.31
초록
The succinic semialdehyde dehydrogenase from bovine brain was inactivated by treatment with phenylglyoxal, a reagent that specifically modifies arginine residues. The inhibition at various phenylglyoxal concentrations shows pseudo-first-order kinetics with an apparent secondorder rate constant of 30