BMB Reports
- Volume 33 Issue 1
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- Pages.49-53
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- 2000
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- 1976-670X(eISSN)
Structure and Antibiotic Activity of a Porcine Myeloid Antibacterial Peptide, PMAP-23 and its Analogues
- Shin, Song-Yub (Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
- Kang, Joo-Hyun (Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
- Jang, So-Yun (Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
- Kim, Kil-Lyong (Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
- Hahm, Kyung-Soo (Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology)
- Received : 1999.07.31
- Accepted : 1999.09.17
- Published : 2000.01.31
Abstract
PMAP-23 is a 23-residue antimicrobial peptide derived from porcine myloid cells. In order to investigate the effects of two Pro residues at positions 12 and 15 of PMAP-23 on antibiotic activity, two analogues in which Ala was substituted for Pro residue at position 12 or 15 were synthesized.
Keywords
- Antibacterial activity;
- Antitumor activity;
- Phospholipid vesicle-disrupting activity;
- PMAP-23;
- Secondary structure