Clinical and Experimental Reproductive Medicine

  • 제27권2호
  • /
  • Pages.179-182
  • /
  • 2000
  • /
  • 2233-8233(pISSN)
  • /
  • 2233-8241(eISSN)
대한생식의학회 (The Korean Society for Reproductive Medicine)
권호 표지

한국인 조기 난소부전 불임환자에서 황체형성 호르몬 유전자 변이 분석

The Analysis of $LH{\beta}$-subunit Variants in Infertile Patients with Premature Ovarian Failure (POF) in Korea

  • 김남근 (포천중문 의과대학교 생화학교실 및 기초의학연구소 중앙연구실, 차병원 여성의학 연구소) ;
  • 이유진 (포천중문 의과대학교 생화학교실 및 기초의학연구소 중앙연구실) ;
  • 남윤성 (분당 차병원 산부인과 및 불임센타) ;
  • 이숙환 (포천중문 의과대학교 생화학교실 및 기초의학연구소 중앙연구실, 차병원 여성의학 연구소) ;
  • 전혜선 (차병원 여성의학 연구소) ;
  • 박찬 (분당 차병원 산부인과 및 불임센타) ;
  • 김종욱 (구미 차병원 산부인과) ;
  • 이경아 (차병원 여성의학 연구소) ;
  • 고정재 (포천중문 의과대학교 생화학교실 및 기초의학연구소 중앙연구실, 차병원 여성의학 연구소) ;
  • 차광열 (포천중문 의과대학교 생화학교실 및 기초의학연구소 중앙연구실, 차병원 여성의학 연구소)
  • Kim, Nam-Keun (Department of Biochemistry and Central Laboratories, Institute of Medical Research, College of Medicine, Pochon CHA University, Infertility Medical Center and Obstetrics & Gynecology, CHA General Hospital) ;
  • Lee, Eu-Gene (Department of Biochemistry and Central Laboratories, Institute of Medical Research, College of Medicine, Pochon CHA University) ;
  • Nam, Yoon-Sung (Obstetrics & Gynecology and Infertility Medical Center, Pundang CHA General Hospital) ;
  • Lee, Sook-Hwan (Department of Biochemistry and Central Laboratories, Institute of Medical Research, College of Medicine, Pochon CHA University, Infertility Medical Center and Obstetrics & Gynecology, CHA General Hospital) ;
  • Jeon, Hye-Sun (Infertility Medical Center and Obstetrics & Gynecology, CHA General Hospital) ;
  • Park, Chan (Obstetrics & Gynecology and Infertility Medical Center, Pundang CHA General Hospital) ;
  • Kim, Jong-Wook (Department of Obstertics and Gynecology, Kumi CHA General Hospital) ;
  • Lee, Kyung-Ah (Infertility Medical Center and Obstetrics & Gynecology, CHA General Hospital) ;
  • Ko, Jung-Jae (Department of Biochemistry and Central Laboratories, Institute of Medical Research, College of Medicine, Pochon CHA University, Infertility Medical Center and Obstetrics & Gynecology, CHA General Hospital) ;
  • Cha, Kwang-Yul (Department of Biochemistry and Central Laboratories, Institute of Medical Research, College of Medicine, Pochon CHA University, Infertility Medical Center and Obstetrics & Gynecology, CHA General Hospital)
  • 발행 : 2000.06.30
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초록

This study was performed to determine whether the $LH{\beta}$-subunit gene missense mutation is present in Korean infertile patients with 46,XX POF women. The variants of $LH{\beta}$ exon 2 (Trp 8Arg; TGG to CGG and Ile15Thr; ATC to ACC) were studied in forty-four 46,XX idiopathic POF and 54 nonpregnant women. The $LH{\beta}$ exon 2 variants were more frequent in POF patients (20.5%) than nonpregnant (16.7%) women (p>0.05). POF patients with the variant was slightly higher than nonpregnant women with the variant.

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