Tuberculosis and Respiratory Diseases
- 제49권3호
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- Pages.310-322
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- 2000
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- 1738-3536(pISSN)
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- 2005-6184(eISSN)
인체 폐암조직에서 Phospholipase C 동위효소의 발현양상
Expression of Phospholipase C Isozymes in Human Lung Cancer Tissues
- 황성철 (아주대학교 의과대학 호흡기내과학교실) ;
- 마경애 (아주대학교 의과대학 호흡기내과학교실) ;
- 최소연 (아주대학교 의과대학 호흡기내과학교실) ;
- 오윤정 (아주대학교 의과대학 호흡기내과학교실) ;
- 최영인 (아주대학교 의과대학 호흡기내과학교실) ;
- 김덕기 (아주대학교 의과대학 호흡기내과학교실) ;
- 이형노 (아주대학교 의과대학 호흡기내과학교실) ;
- 최영화 (아주대학교 의과대학 호흡기내과학교실) ;
- 박광주 (아주대학교 의과대학 호흡기내과학교실) ;
- 이이형 (아주대학교 의과대학 호흡기내과학교실) ;
- 이기범 (아주대학교 의과대학 해부병리학교실) ;
- 하만준 (아주대학교 의과대학 의학유전학교실) ;
- 배윤수 (이화여대 생물학교실)
- Hwang, Sung-Chul (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
- Mah, Kyung-Ae (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
- Choi, So-Yeon (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
- Oh, Yoon-Jung (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
- Choi, Young-In (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
- Kim, Deog-Ki (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
- Lee, Hyung-Noh (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
- Choi, Young-Hwa (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
- Park, Kwang-Ju (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
- Lee, Yi-Hyeong (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
- Lee, Kyi-Beom (Department of Anatomic Pathology, Ajou University School of Medicine) ;
- Ha, Mahn-Joon (Department of Laboratory of Medical Genetics, Ajou University School of Medicine) ;
- Bae, Yoon-Su (Department of Biological Sciences, Ehwa Womans University)
- 발행 : 2000.09.30
초록
배경 : Phospholipase C는 세포내 신호 전달과정의 초기 단계에 있어서, 매우 중요한 역할을 하는 효소로 알려져 있으며, 세포막에 존재하는 인지질 가운데 중요한 부분을 차지하는
Background : Phospholipase C(PLC) plays an important role in cellular signal transduction and is thought to be critical in cellular growth, differentiation and transformation of certain malignancies. Two second messengers produced from the enzymatic action of PLC are diacylglycerol (DAG) and inositol 1, 4, 5-trisphosphate (IP3). These two second messengers are important in down stream signal activation of protein kinase C and intracellular calcium elevation. In addition, functional domains of the PLC isozymes, such as Src homology 2 (SH2) domain, Src homology 3 (SH3) domain, and pleckstrin homology (PH) domain play crucial roles in protein translocation, lipid membrane modificailon and intracellular memrane trafficking which occur during various mitogenic processes. We have previously reported the presence of PLC-