The Korean Journal of Pain
- 제13권2호
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- Pages.164-174
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- 2000
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- 2005-9159(pISSN)
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- 2093-0569(eISSN)
Complete Freund Adjuvant에 의한 피부염증에서 통각과민현상의 기전
Mechanism of Hyperalgesia Following Cutaneous Inflammation by Complete Freund Adjuvant
- 정용 (연세대학교 의과대학 신경과학교실) ;
- 임중우 (연세대학교 의과대학 생리학교실) ;
- 정승수 (연세대학교 의과대학 생리학교실) ;
- 김윤숙 (연세대학교 의과대학 생리학교실) ;
- 윤덕미 (연세대학교 의과대학 마취과학교실) ;
- 남택상 (연세대학교 의과대학 생리학교실) ;
- 백광세 (연세대학교 의과대학 생리학교실)
- Jeong, Yong (Department of Neurology, Yonsei University College of Medicine) ;
- Leem, Joong-Woo (Department of Physiology, Yonsei University College of Medicine) ;
- Chung, Seung-Soo (Department of Physiology, Yonsei University College of Medicine) ;
- Kim, Yun-Suk (Department of Physiology, Yonsei University College of Medicine) ;
- Yoon, Duck-Mi (Department of Anesthesiology, Yonsei University College of Medicine) ;
- Nam, Taick-Sang (Department of Physiology, Yonsei University College of Medicine) ;
- Paik, Kwang-Se (Department of Physiology, Yonsei University College of Medicine)
- 발행 : 2000.11.30
초록
Background: After an injury to tissue such as the skin, hyperalgesia develops. Hyperalgesia is characterized by an increase in the magnitude of pain evoked by noxious stimuli. It has been postulated that in the mechanism of hyperalgesia (especially secondary hyperalgesia) and allodynia, a sensitization of central nervous system such as spinal dorsal horn may contribute to development of hyperalgesia. However, the precise mechanism is still unclear. In the present study, we investigated the roles of N-methyl-D-aspartate (NMDA) receptor and nitric oxide (NO) system in the mechanism of hyperalgesia, and their relations with c-fos expression Methods: Inflammation was induced by injection of complete Freund adjuvant (CFA) into unilateral hindpaw of Sprague-Dawley rat. Behavioral studies measuring paw withdrawal responses by von Frey filaments and paw withdrawal latencies by radiant heat stimuli and stainings of nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase and c-fos immunoreactivity were performed. The effects of MK-801, an NMDA receptor blocker and