The Korean Journal of Pain
- Volume 13 Issue 2
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- Pages.156-163
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- 2000
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- 2005-9159(pISSN)
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- 2093-0569(eISSN)
Sympathetic Dependency of Cold-evoked Pain Behavior Seen in Rats with Peripheral Neuropathy
신경병증성통증 모델쥐에서 냉자극 유발 통증의 교감신경성 의존도
- Choi, Byung-Ock (Department of Physiology, Yonsei University College of Medicine) ;
- Choi, Yoon (Department of Anesthesiology, Ulsan University College of Medicine) ;
- Gwak, Young-Seob (Department of Physiology, Yonsei University College of Medicine) ;
- Nam, Taick-Sang (Department of Physiology, Yonsei University College of Medicine) ;
- Paik, Kwang-Se (Department of Physiology, Yonsei University College of Medicine) ;
- Leem, Joong-Woo (Department of Physiology, Yonsei University College of Medicine)
- 최병옥 (연세대학교 의과대학 생리학교실) ;
- 최윤 (울산대학교 의과대학 마취과학교실) ;
- 곽영섭 (연세대학교 의과대학 생리학교실) ;
- 남택상 (연세대학교 의과대학 생리학교실) ;
- 백광세 (연세대학교 의과대학 생리학교실) ;
- 임중우 (연세대학교 의과대학 생리학교실)
- Published : 2000.11.30
Abstract
Background: Peripheral nerve injury sometimes leads to chronic neuropathic pain such as causalgia. A subset of patients with causalgia have a sympathetically maintained pain which is often evoked by cooling stimuli. However, our knowledge on adrenergic receptor types responsible for cold-evoked pain that is sympathetically dependent is lacking. The present study was conducted to investigate subtypes of adrenoceptors involved in mediating cold-evoked pain that developed following peripheral nerve injury. Methods: Neuropathic surgery was performed by a unilateral ligation of L5 and L6 spinal nerves of rats. Behavioral sign of cold-evoked pain was examined for 5 min by measuring cumulative duration of time that the rat lifted its foot off a metal plate held at cold temperature (