The Korean Journal of Pain
- 제13권1호
- /
- Pages.19-30
- /
- 2000
- /
- 2005-9159(pISSN)
- /
- 2093-0569(eISSN)
신경병성 통증모델쥐에서 산화질소합성효소 억제제가 척수후각세포의 활성도에 미치는 영향
Effects of NO Synthase Inhibitor on Responsiveness of Dorsal Horn Neurons in Neuropathic Pain Animal Model
-
임중우
(연세대학교 의과대학 생리학교실) ;
- 곽영섭 (연세대학교 의과대학 생리학교실) ;
- 정승수 (연세대학교 의과대학 생리학교실) ;
- 이규래 (연세대학교 의과대학 생리학교실) ;
- 윤덕미 (연세대학교 의과대학 마취과학교실) ;
-
남택상
(연세대학교 의과대학 생리학교실)
-
Leem, Joong-Woo
(Department of Physiology, Yonsei University College of Medicine) ;
- Gwak, Young-Seob (Department of Physiology, Yonsei University College of Medicine) ;
- Chung, Seung-Soo (Department of Physiology, Yonsei University College of Medicine) ;
- Lee, Kyu-Rae (Department of Physiology, Yonsei University College of Medicine) ;
- Yoon, Duck-Mi (Department of Anesthesiology, Yonsei University College of Medicine) ;
-
Nam, Taick-Sang
(Department of Physiology, Yonsei University College of Medicine)
- 발행 : 2000.06.30
초록
Background: Partial nerve injury to a peripheral nerve may induce the development of neuropathic pain which is characterized by symptoms such as spontaneous burning pain, allodynia and hyperalgesia. Though underlying mechanism has not fully understood, sensitization of dorsal horn neurons may contribute to generate such symptoms. Nitric oxide acts as an inter- and intracellular messenger in the nervous system and is produced from L-arginine by nitric oxide synthase (NOS). Evidence is accumulating which indicate that nitric oxide may mediate nociceptive information transmission. Recently, it has been reported that NOS inhibitor suppresses neuropathic pain behavior in an neuropathic pain animal model. This study was conducted to determine whether nitric oxide could be involved in the sensitization of dorsal horn neurons in neuropathic animal model. Methods: Neuropathic animal model was made by tightly ligating the left L5 and L6 spinal nerves and we examined the effects of iontophoretically applied NOS inhibitor (L-NAME) on the dorsal horn neuron's responses to mechanical stimuli within the receptive fields. Results: In normal animals, NOS inhibitor (L-NAME) specifically suppressed the responses to the noxious mechanical stimuli. In neuropathic animals, the dorsal horn neuron's responses to mechanical stimuli were enhanced and NOS inhibitor suppressed the dorsal horn neuron's enhanced responses to non-noxious stimuli as well as those to noxious ones. Conclusions: These results suggest that nitric oxide may mediate nociceptive transmission in normal animal and also mediate sensitization of dorsal horn neurons in neuropathic pain state.