대한두경부종양학회지 (Korean Journal of Head & Neck Oncology)

  • 제16권1호
  • /
  • Pages.9-13
  • /
  • 2000
  • /
  • 1229-5183(pISSN)
  • /
  • 2586-2553(eISSN)
대한두경부종양학회 (The Korean Society for Head and Neck Oncology)
권호 표지

두경부 악성 종양 조직내 간질액 압력

Tumor Interstitial Fluid Pressure in Patients with Head and Neck Cancer

  • 조문준 (충남대학교 의과대학 치료방사선과학교실) ;
  • 김재성 (충남대학교 의과대학 치료방사선과학교실) ;
  • 이인태 (펜실바니아대학 의과대학 치료방사선과학교실) ;
  • 김준상 (충남대학교 의과대학 치료방사선과학교실) ;
  • 장지영 (충남대학교 의과대학 치료방사선과학교실) ;
  • 김기환 (충남대학교 의과대학 치료방사선과학교실)
  • Cho Moon-June (Department of Therapeutic Radiology, College of Medicine, Chungnam National University) ;
  • Kim Jae-Sung (Department of Therapeutic Radiology, College of Medicine, Chungnam National University) ;
  • Lee In-Tae (Department of Radiation Oncology, School of Medicine, University of Pennsylvania) ;
  • Kim Jun-Sang (Department of Therapeutic Radiology, College of Medicine, Chungnam National University) ;
  • Jang Ji-Young (Department of Therapeutic Radiology, College of Medicine, Chungnam National University) ;
  • Kim Ki-Hwan (Department of Therapeutic Radiology, College of Medicine, Chungnam National University)
  • 발행 : 2000.05.01
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초록

Objectives: To determine the tumor interstitial fluid pressure(TIFP) in patients with head and neck cancerand predict radiotherapy outcome.Materials and Methods: In 12 biopsy proven primary head and neck cancer patients with accessible by direct inspection and palpation, and of sufficient thickness(>1cm) to permit accurate needle placement, we measured TIFP at cervical lymph node before and during radiotherapy using a modified wick-in-needle technique. Tumor size was measured clinically and radiologically. Results: The mean preradiotherapy TIFP was 23.4mmHg. Preradiotherapy TIFP had significant relationship with tumor size(p=0.0009). Preradiotherapy TIFP was not different between complete response group and partial or less response group(p=0.114). Radiotherapy outcome was not different between group with above and group with below average TIFP(p=0.09). Conclusion: The mean TIFP was elevated with 23.4mmHg before radiation therapy. Preradiotherapy TIFP had significant relationship with tumor size. It is not definitive that TIFP could be prognostic indicator of radiation response.

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