Journal of Korean Neurosurgical Society
- Volume 29 Issue 10
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- Pages.1303-1308
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- 2000
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- 2005-3711(pISSN)
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- 1598-7876(eISSN)
Expression of Vascular Endothelial Growth Factor in Astrocytic Tumors - Correlation to Peritumoral Brain Edema and Microvasculature -
성상세포종양에서 혈관내피증식인자의 발현 - 종양주변부 부종 및 미세혈관과의 상관관계 -
- Kim, Tae Young (Department of Neurosurgery, School of Medicine, Wonkwang University) ;
- Park, Jong Tae (Department of Neurosurgery, School of Medicine, Wonkwang University) ;
- Moon, Seong Keun (Department of Neurosurgery, School of Medicine, Wonkwang University) ;
- Han, Weon Cheol (Department of Anatomical Pathology, School of Medicine, Wonkwang University)
- Received : 2000.06.05
- Accepted : 2000.10.13
- Published : 2000.10.28
Abstract
Objectives : It has been known that vascular endothelial growth factor(VEGF), as an endothelial cell-specific mitogen, induces angiogenesis, and possesses vascular permeability and procoagulant properties. Peritumoral brain edema(PTBE) is a common accompaniment of malignant gliomas. It results from microvascular extravasation of plasma and proteins through the interendothelial spaces. The correlation between pathological grading, PTBE, neovascularization, and the expression of VEGF were analyzed in 31 patients with astrocytic tumors. Methods : Astrocytic tumor samples(8 astrocytomas, 14 anaplastic astrocytomas, and 9 glioblastomas) from 31 patients( 21 males and 10 females : average age
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