소아의 원발성 악성 연수막 흑색종 - 증 례 보 고 -

Primary Malignant Leptomeningeal Melanoma in a Child - A Case Report -

  • 손영제 (서울대학교 의과대학 신경외과학교실) ;
  • 왕규창 (서울대학교 의과대학 신경외과학교실) ;
  • 김연미 (서울대학교 의과대학 병리학교실) ;
  • 신상훈 (서울대학교 의과대학 신경외과학교실) ;
  • 지제근 (서울대학교 의과대학 병리학교실) ;
  • 조병규 (서울대학교 의과대학 신경외과학교실)
  • Son, Young-Je (Department of Neurosurgery, Seoul National University College of Medicine) ;
  • Wang, Kyu-Chang (Department of Neurosurgery, Seoul National University College of Medicine) ;
  • Kim, Youn Mee (Department of Pathology, Seoul National University College of Medicine) ;
  • Shin, Sang-Hoon (Department of Neurosurgery, Seoul National University College of Medicine) ;
  • Chi, Je G. (Department of Pathology, Seoul National University College of Medicine) ;
  • Cho, Byung-Kyu (Department of Neurosurgery, Seoul National University College of Medicine)
  • 투고 : 1999.10.21
  • 심사 : 2000.01.07
  • 발행 : 2000.09.28

초록

Primary malignant leptomeningeal melanoma is very rare, accounting for less than 0.1 percent of tumors in the central nervous system. Patients with primary intracranial malignant melanoma tend to be younger than metastatic intracranial melanoma, most commonly in the fourth decade of life. This tumor is extremely rare and the biologic behavior is aggressive especially in children. The authors report a case of primary malignant leptomeningeal melanoma in a twelve-year-old boy which was initially diagnosed as meningitis. On autopsy, associated extensive leptomeningeal melanosis was confirmed and believed to be the origin of the tumor. This case emphasizes the pattern of clinical presentation and the significance of leptomeningeal melanosis in primary leptomeningeal melanoma.

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