Journal of Korean Neurosurgical Society

  • 제29권4호
  • /
  • Pages.485-490
  • /
  • 2000
  • /
  • 2005-3711(pISSN)
  • /
  • 1598-7876(eISSN)
대한신경외과학회 (The Korean Neurosurgical Society)
권호 표지

성상교세포종에서 Apoptosis와 Bcl-2 발현

Apoptosis and Bcl-2 in Astrocytic Tumors

  • 장연규 (연세대학교 원주의과대학 신경외과학교실) ;
  • 황금 (연세대학교 원주의과대학 신경외과학교실) ;
  • 홍순원 (연세대학교 원주의과대학 해부병리학교실)
  • Jang, Yeon Gyoe (Department of Neurosurgery, Wonju College of Medicine, Yonsei University) ;
  • Whang, Kum (Department of Neurosurgery, Wonju College of Medicine, Yonsei University) ;
  • Hong, Soon-Won (Department of Pathology, Wonju College of Medicine, Yonsei University)
  • 투고 : 1999.11.15
  • 심사 : 2000.01.14
  • 발행 : 2000.04.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objective : To study the expression of apoptosis and bcl-2 in the astrocytic tumors. Patients and Methods : A total of thirty-eight astrocytomas(9 cases in low grade astrocytoma, 12 cases in anaplastic astrocytoma and 17 cases in glioblastoma) are included in this study. Immunohistochemical stain for bcl-2 using monoclonal antibody, in situ end labelling technique for apoptosis were used. Results : The malignant group(anaplastic astrocytoma and glioblastoma) showed significantly higher apoptosis positive index(PI) compared to the benign group(low grade astrocytoma)(1.35 vs 0.14). However apoptosis PI and bcl-2 PI were not significantly different among three groups. Correlation between apoptosis PI and bcl-2 PI was not statistically significant(p=0.58). Conclusion : This result suggest that apoptosis PI and bcl-2 PI are not related the degree of malignancy in astrocytic neoplasm, but apoptosis PI in malignant group was higher possibly due to greater DNA damage.

키워드