Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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The Effects of Lipoxygenase and Cyclooxygenase Inhibitors to Meningioma Cell Proliferation in vitro

Lipoxygenase 및 Cyclooxygenase Inhibitor가 뇌수막종세포의 성장에 미치는 영향

  • Park, Yong Seok (Department of Neurosurgery, Dongguk University Hospital) ;
  • Koo, Tae Heon (Department of Neurosurgery, Dongguk University Hospital) ;
  • Lee, Jung Hoon (Department of Neurosurgery, Cleveland Clinic) ;
  • Lee, Young Bae (Department of Neurosurgery, Dongguk University Hospital) ;
  • Lee, Kyu Chun (Department of Neurosurgery, Dongguk University Hospital) ;
  • Mok, Jin Ho (Department of Neurosurgery, Dongguk University Hospital) ;
  • Kim, Han Sik (Department of Neurosurgery, Dongguk University Hospital)
  • 박용석 (동국대학교 의과대학 신경외과학교실) ;
  • 구태헌 (동국대학교 의과대학 신경외과학교실) ;
  • 이정훈 (클리브랜드 클리닉 신경외과) ;
  • 이영배 (동국대학교 의과대학 신경외과학교실) ;
  • 이규춘 (동국대학교 의과대학 신경외과학교실) ;
  • 목진호 (동국대학교 의과대학 신경외과학교실) ;
  • 김한식 (동국대학교 의과대학 신경외과학교실)
  • Received : 1999.04.21
  • Accepted : 1999.06.23
  • Published : 2000.01.28
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Abstract

Object : To verify the effect of the lipoxygenase inhibitor and cycloxygenase inhibitor on meningioma cell proliferation. Method : Using two meningioma cell lines, cell proliferation was determined at 96 hrs after adding inhibitor (AA861, Nordihydroguaiaretic acid(NDGA), Indomethacin, acetyl-11-keto-beta-boswellic acid(AKBA) into medium by methyl tetrazolium salt/phenazine methosulfate(MTS/PMS) non-radioactive cell proliferation assay. We checked optical density with 490nm wavelength UV and this value was used as a proliferative index. The percent of inhibition was also calculated from this value. Conclusion : Indomethacin and NDGA showed no effect on meningioma proliferation. AA861 also showed no significant inhibitory effect, but AKBA demonstrated a significant inhibitory effect on meningioma cell proliferation.

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