Annals of Clinical Neurophysiology
- Volume 2 Issue 2
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- Pages.119-124
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- 2000
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- 2508-691X(pISSN)
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- 2508-6960(eISSN)
EEG Patterns of High dose Pilocarpine-Induced Status Epilepticus in Rats
흰쥐에서 고용량의 Pilocarpine에 의하여 유발된 간질중첩증의 양상
- Lee, Kyung-Mok (Department of Neurology, Chungnam National University Hospital) ;
- Jung, Ki-Young (Department of Neurology, Chungnam National University Hospital) ;
- Kim, Jae-Moon (Department of Neurology, Chungnam National University Hospital)
- Published : 2000.11.30
Abstract
Background : We studied EEG changes during pilocarpine-induced status epilepticus(SE), a widely used model whose EEG characteristics have not been fully described previously. Methods : Male Sprague-Dawley rats weighing 250-350 grams were used as subjects. SE was induced 5-7 days after placement of chronic epidural electrodes, using 360-380 mg/Kg pilocarpine IP. Rats were observed with continuous EEG recording following pilocarpine injection until end of the SE episode. Results : SE occurred in 10/12 rats studied. SE began with a series of discrete seizures